中国血液净化

中国血液净化 ›› 2023, Vol. 22 ›› Issue (06): 446-449.doi: 10.3969/j.issn.1671-4091.2023.06.010

• 综述 • 上一篇    下一篇

小动物模型在血液透析血管通路研究的应用现状

秦 宇    杜 静    赵战云   

  1. 261053 潍坊，1潍坊医学院临床医学院
    261044 潍坊，2潍坊市人民医院血液净化中心
  • 收稿日期:2023-01-03 修回日期:2023-01-15 出版日期:2023-06-12 发布日期:2023-06-12
  • 通讯作者: 赵战云 E-mail:zhaoyun661@sina.com
  • 基金资助:
    潍坊市卫生委员会科研项目计划(WFWSJK-2020-047)

Application of small animal models in the study of vascular access for hemodialysis

QIN Yu, DU Jing, ZHAO Zhan-yun   

  1. School of Clinical Medicine, Weifang Medical University, Weifang 261053, China; 2Department of Blood Purification Center, Weifang People’s Hospital, Weifang 261044, China
  • Received:2023-01-03 Revised:2023-01-15 Online:2023-06-12 Published:2023-06-12
  • Contact: 61044 潍坊，2潍坊市人民医院血液净化中心 E-mail:zhaoyun661@sina.com

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摘要： 血液透析患者的血管通路方式包括自体动静脉内瘘(arteriovenous fistula,AVF)、移植物动静脉内瘘(arteriovenous graft,AVG)和中心静脉导管(central venous catheter,CVC)。但各种类型血管通路均面临反复失功的问题，且失功的发生机制尚未阐明。动物模型可以提高对血管通路失功的认识，而其中的小动物模型，因具有更好的操作性和成本效益，在血管通路相关分子机制研究中具有优势。本综述重点阐述血液透析血管通路中几种常见的小动物模型，并讨论了这些模型的研究现状及特点。

关键词: 血管通路, 小动物模型, 血液透析, 慢性肾脏病

Abstract: Vascular access for hemodialysis patients includes arteriovenous fistula (AVF), arteriovenous graft (AVG) and central venous catheter (CVC), but all the vascular access methods have the problem of dysfunction. The mechanism of blood access failure is unclear. Animal model can be helpful to understand the causes of vascular access failure. Small animal model has the advantages of easy to use and less expensive, suitable for the molecular study of blood access failure. This review introduces several small animal models as well as the research status and characteristics of the small animal models for the study of blood access failure.

Key words: Vascular access, Small animal model, Hemodialysis, Chronic kidney disease

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