中国血液净化

中国血液净化 ›› 2021, Vol. 20 ›› Issue (12): 797-800.doi: 10.3969/j.issn.1671-4091.2021.12.002

• 专题与讲座·党为人民谋健康的100年 • 上一篇    下一篇

局部枸橼酸抗凝在连续性肾脏替代治疗中的应用要点#br#

李镇洲1,2,万建新1,2   

  1. 福建医科大学附属第一医院1肾内科2血液净化研究中心
  • 收稿日期:2021-09-27 修回日期:2021-10-08 出版日期:2021-12-12 发布日期:2021-12-03
  • 通讯作者: 万建新 wanjx@263.net E-mail:wanjx@263.net

Application of local citrate anticoagulation in continuous renal replacement therapy

  1. 1Department of Nephrology and 2Blood Purification Research Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350000, China
  • Received:2021-09-27 Revised:2021-10-08 Online:2021-12-12 Published:2021-12-03

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摘要： 【摘要】体外循环抗凝是连续性肾脏替代治疗(continuerenal replacement therapy,CRRT)顺利实施的重要环节，不合适的抗凝方案可导致患者体外循环凝血、血液丢失、血液高凝、血栓栓塞性疾病，严重者可危及生命。局部枸橼酸抗凝(regional citrate anticoagulation，RCA)由于具有抗凝效果确切、出血风险小等优势，在CRRT 中广泛应用，特别适用于合并高出血风险疾病的患者，但目前在临床上应用方案尚无统一标准。本文就CRRT 中应用RCA 的技术要点和相关注意事项进行简要介绍，以便更好地指导临床应用。

关键词: 抗凝, 局部枸橼酸抗凝, 连续性肾脏替代治疗

Abstract: 【Abstract】Anticoagulation in extracorporeal circulation is an important step for successful implementation of continuous renal replacement therapy (CRRT). Inappropriate anticoagulation regimen will cause blood coagulation in extracorporeal circulation, blood loss, hypercoagulation status or thromboembolic diseases, which are life-threatening in severe cases. Regional citrate anticoagulation (RCA) with its advantages of effective anticoagulation and lower bleeding risk is widely used in CRRT, especially for patients with bleeding risk. However, there are no standard protocols yet for clinical application. This article briefly introduces the
technical essentials and precautions of RCA for its better use in CRRT.

Key words: Anticoagulation, Regional citrate anticoagulation, Continuous renal replacement therapy

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