中国血液净化

›› 2007, Vol. 6 ›› Issue (2): 71-72.

• 论著 • 上一篇    下一篇

缬沙坦对尿毒症维持性血液透析患者微炎症状态的影响

陆 红 解汝娟   

  1. 150001 哈尔滨，哈尔滨医科大学第一临床医学院肾内科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2007-02-12 发布日期:2007-02-12

  • Received:1900-01-01 Revised:1900-01-01 Online:2007-02-12 Published:2007-02-12

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摘要： 目的 观察缬沙坦治疗对尿毒症维持性血液透析患者微炎症状态的影响,探讨血管紧张素Ⅱ(AngiotensinⅡ,AngⅡ)1 型受体拮抗剂(AT1RA)在治疗尿毒症患者微炎症状态中的作用。方法 选择哈尔滨医科大学附属第一医院肾内科维持性血液透析患者56例, 测定C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平后，随机分为缬沙坦治疗组和非缬沙坦治疗组。用药后24周检查CRP、IL-6、TNF-α。并设30例健康者作对照比较。结果 ①尿毒症维持性血液透析患者CRP、IL-6、TNF-α显著高于健康者(P＜0.01)；②治疗后24周，缬沙坦治疗组CRP、IL-6、TNF-α的水平均有所下降，缬沙坦治疗组CRP、IL-6、TNF-α下降的水平与治疗前及非治疗组相比，差异具有显著性(P＜0.05)。结论 应用缬沙坦治疗能改善尿毒症患者的微炎症状态。

关键词: 缬沙坦, 维持性血液透析, 微炎症状态

Abstract: Objective To investigate the effects of valsartan on microinflammation state in maintenance hemodialysis patients. Methods In 56 patients maintenance hemodialysis patients and 30 healthy control subjects the levels of C-reactive protein (CRP),Interlukin-6(IL-6),tumor necrosis factor alpha(TNF-α) were determined,then the patients were randomly divided into 2 groups to receive valsartan 80mg daily or non-valsartan theraphy.All above parametes were assayed again after 24 weeks. Results ①Compared with healthy people,the serum CRP,IL-6,TNF-α were elevated significantly in patients with maintenance hemodialysis. ② After 24 weeks’treatment, the levels of CRP,IL-6,TNF-α in valsavtan group was lower than before,and the levels of CRP,IL-6, TNF-α were much lower in valsavtan group than non-valsartan group (P＜0.05). Conclusion Valsartan can relieve the microinflammation state in maintenance hemodialysis patients.

Key words: Maintenance hemodialysis, Microinflammation

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