中国血液净化

中国血液净化 ›› 2026, Vol. 25 ›› Issue (02): 125-127.doi: 10.3969/j.issn.1671-4091.2026.02.008

• 临床研究 • 上一篇    下一篇

氢氧气吸入对维持性血液透析患者微炎症状态和营养的改善效果分析

赵 慧   王晨晖   陈 蓉   秦晓鸥   刘艳琴   刘静娟   高琳琳   王保国   

  1. 102299 北京，1 泰康燕园康复医院肾内科 100093 北京，2 首都医科大学三博脑科医院麻醉科
  • 收稿日期:2025-06-25 修回日期:2025-09-05 出版日期:2026-02-12 发布日期:2026-02-02
  • 通讯作者: 王保国 E-mail:wbgttyy@163.com

Effects of hydrogen and oxygen inhalation on nutrition and microinflammation in maintenance hemodialysis patients

ZHAO Hui, WANG Chen-hui, CHEN Rong, QIN Xiao-ou, LIU Yan-qin, LIU Jing-juan, GAO Lin-lin, WANG Bao-guo   

  1. Department of Nephrology, Taikang Yanyuan Rehabilitation Hospital Beijing, Beijing 102299, China; 2Department of Anesthesiology, Sanbo Brain Hospital, Capital Medical University, Beijing 100093, China
  • Received:2025-06-25 Revised:2025-09-05 Online:2026-02-12 Published:2026-02-02
  • Contact: 100093 北京，2首都医科大学三博脑科医院麻醉科 E-mail:wbgttyy@163.com

摘要： 目的 分析维持性血液透析(maintenance hemodiaysis，MHD)患者吸入氢氧气对其营养和微 炎症状态的改善效果。 方法 选择北京泰康燕园康复医院血液透析室规律进行血液透析的病情稳定的 MHD患者。受试者每次血液透析时吸入氢氧气体(3 L/min，氢氧气比例为2：1)120 min，持续1个月，收集 治疗前及治疗1、2个月炎症及营养指标。 结果 共入选37例患者，完成试验患者32例(男性25例，女性 7例)。平均年龄(64.4±12.2)岁，平均透析龄(60.1±49.5)月。受试者在治疗开始后的第1个月的透析 前血白蛋白较基线升高(t=2.362，P=0.025)，在第2个月继续升高(t=6.813，P＜0.001)。血小板/白蛋白 (platelet/albumin，PAR)治 疗 后 的 第 1 个 月 较 基 线 下 降(t=0.252，P=0.802)，第 2 个 月 下 降 至 更 低(t= 2.906,P=0.007)。 结论 为维持性血液透析患者吸入氢氧气可能改善患者的微炎症状态及营养状况。

关键词: 血液透析, 吸入氢氧气, 营养, 微炎症

Abstract: 【Abstract】Objective To analyze the effect of hydrogen and oxygen inhalation on nutrition and microinflammation in maintenance hemodialysis (MHD) patients. Methods The stable MHD patients who underwent regular hemodialysis in the Hemodialysis Center of Beijing Taikang Yanyuan Rehabilitation Hospital were enrolled in this study. Every subject inhaled hydrogen and oxygen gases (3L/min, hydrogen: oxygen=2: 1) for 120 min during hemodialysis session for one month, and the subjects were observed and followed up for 6 months. Results A total of 37 patients were enrolled in this study, and 32 patients (25 males and 7 females) completed the trial. Their mean age was 64.4±12.2 years, and mean dialysis age was 60.1±49.5 months. In the first month after the start of treatment, serum albumin increased significantly compared to the baseline value (t=2.362, P=0.025). Serum albumin increased further in the second month (t=6.813, P＜0.001). Platelet/albumin (PAR) began to decline in the first month after treatment (t=0.252, P=0.802), and decreased further in the second month (t=2.906, P=0.007). Conclusion Inhalation of hydrogen and oxygen may improve nutrition and microinflammation status in MHD patients.

Key words: Hemodialysis, Nutrition, Microinflammation, Hydrogen and oxygen inhalation

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