中国血液净化

中国血液净化 ›› 2026, Vol. 25 ›› Issue (02): 156-159.doi: 10.3969/j.issn.1671-4091.2026.02.015

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尿毒症肿瘤样钙化：病理机制与临床管理进展

莫宇毅   陆 君   林劲天   黄海庭   

  1. 533000 百色，右江民族医学院 1研究生学院 2招生与就业服务指导中心  533000 百色，3右江民族医学院附属医院肾内科  533000 百色，4广西免疫相关性疾病研究医学科研基础保障重点(培育)实验室

  • 收稿日期:2025-07-18 修回日期:2025-10-10 出版日期:2026-02-12 发布日期:2026-02-02
  • 通讯作者: 黄海庭 E-mail:hhtwsw123@126.com
  • 基金资助:

Uremic tumoral calcinosis: pathophysiological mechanisms and advances in clinical management

MO Yu-yi, LU Jun, LIN Jing-tian, HUANG Hai-ting   

  1. 1 Graduate School, and 2 Admission and Career Services Guidance Center, Youjiang Medical University for Nationalities, Baise 533000, China; 3 Department of Nephrology, the Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, China; 4 Key Laboratory of Medical Research Basic Guarantee for Immune- Related Diseases Research of Guangxi (Cultivation), Baise 533000, China
  • Received:2025-07-18 Revised:2025-10-10 Online:2026-02-12 Published:2026-02-02
  • Contact: 533000 百色，3右江民族医学院附属医院肾内科；533000 百色，4广西免疫相关性疾病研究医学科研基础保障重点(培育)实验室 E-mail:hhtwsw123@126.com

摘要： 尿毒症肿瘤样钙化(uremic tumoral calcinosis,UTC)是一种少见的终末期肾病并发症，表
现为大关节周围无痛性钙盐沉积团块，其核心驱动因素是血磷及钙磷乘积升高。诊断需结合透析病史、
临床表现、影像学检查，以及血清钙、磷、甲状旁腺激素和碱性磷酸酶等指标。治疗目标在于协同控制血
磷、血钙及矿物质-骨代谢，主要措施包括非钙类磷结合剂、低钙透析、甲状旁腺切除术、肾移植及病灶切
除等。由于缺乏大样本对照研究，UTC的最佳管理策略仍有待进一步验证。

关键词: 尿毒症肿瘤样钙化, 终末期肾病, 软组织钙化, 继发性甲状旁腺功能亢进, 钙磷乘积

Abstract: Uremic tumoral calcinosis (UTC) is a rare complication of end-stage renal disease, characterized by painless calcium salt deposits around large joints. Its core driving factor is elevated serum phosphate and calcium-phosphate product. Diagnosis requires a combination of dialysis history, clinical manifestations, imaging examinations, and laboratory indicators including serum calcium, phosphate, parathyroid hormone, and alkaline phosphatase. The therapeutic goal is to jointly control serum phosphate, serum calcium, and mineral-bone metabolism. Major approaches include non-calcium-based phosphate binders, low-calcium dialysis, parathyroidectomy, kidney transplantation, and lesion excision. Due to the lack of large-scale controlled studies, the optimal management strategy for UTC remains to be further validated

Key words: Uremic tumoral calcinosis, End-stage renal disease, Soft tissue calcification, Secondary hyperparathyroidism, Calcium-phosphorus product

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