中国血液净化

中国血液净化 ›› 2026, Vol. 25 ›› Issue (04): 284-0.doi: 10.3969/j.issn.1671-4091.2026.04.003

• 临床研究 • 上一篇    下一篇

维持性血液透析患者血清反三碘甲状腺原氨酸水平与肌肉减少症的关联

何晓娇   李 双   邱振梁   刘 云   钟小仕   

  1. 510220 广州，暨南大学附属广州红十字会医院1肾内科 2临床病态营养研究所
  • 收稿日期:2025-06-24 修回日期:2025-12-16 出版日期:2026-04-12 发布日期:2026-04-12
  • 通讯作者: 钟小仕 E-mail:2453075701@qq.com
  • 基金资助:
    广州市科技计划项目

Maintenance hemodialysis patients with lower serum reverse triiodothyronine levels are independently associated with sarcopenia

HE Xiao-jiao, LI Shuang, QIU Zhen-liang, LIU Yun, ZHONG Xiao-shi   

  1. Department of Nephrology, 2Institute of Clinical Pathological Nutrition, Guangzhou Red Cross Hospital of Jinan University, Guangzhou 510220, China
  • Received:2025-06-24 Revised:2025-12-16 Online:2026-04-12 Published:2026-04-12
  • Contact: 510220 广州，暨南大学附属广州红十字会医院1肾内科 E-mail:2453075701@qq.com

摘要： 的 探讨维持性血液透析(maintenance hemodialysis，MHD)患者血清反三碘甲状腺原氨酸(reverse triiodothyronine，rT3)水平与肌肉减少症(简称肌少症)的关系。 方法  收集MHD患者的临床资料，采集并记录透析前血清生化指标及甲状腺功能指标，采用身体成分分析仪进行生物电阻抗频谱测量人体成分指标，并测量握力、6 m平均步速。参考亚洲肌少症工作组2019共识，将患者分为肌少组和非肌少症组。应用二元Logistics回归分析各临床指标与MHD患者肌少症的相关性。 结果  肌少症组患者相较于非肌少症组患者，其血清rT3水平较低(t=5.215，P=0.022)。单变量二元logistic分析显示肌少症与血清rT3水平相关(OR=0.610，95%CI：0.386～0.964，P=0.034)，在多变量二元logistic回归分析模型中校正混杂因素后，血清rT3水平与肌少症之间仍独立相关(OR=0.495，95%CI：0.268～0.915，  P=0.024)。 结论  MHD患者血清rT3水平与肌少症独立相关，其具体机制尚需进一步探讨。

关键词: 反三碘甲状腺原氨酸, 肌肉减少症, 维持性血液透析

Abstract: ABSTRACT ： Objective ： To investigate the relationship between serum Reverse Triiodothyronine（rT3）and sarcopenia in the patients undergoing maintenance hemodialysis （MHD）Methods：The clinical data of MHD were collected. Pre-dialysis serum biochemical parameters and thyroid function indicators were systematically obtained and recorded. Body composition was assessed via bioelectrical impedance spectroscopy. Functional metrics included grip strength, 6-meter gait speed. Binary logistic regression identified clinical parameters associated with sarcopenia in MHD Results：Sarcopenia patients showed lower serum rT3 levels than non-sarcopenia controls (P=0.022). Both univariate (P<0.05) and multivariate analyses confirmed an independent inverse association between serum rT3 levels and sarcopenia risk （OR=0.495，95％CI=0.268~0.915，P=0.024）. Conclusion serum rT3 levels in MHD patients are independently linked to sarcopenia, with the underlying mechanism.

Key words: Reverse Triiodothyronine, Sarcopenia, Maintenance Hemodialysis

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