中国血液净化

中国血液净化 ›› 2026, Vol. 25 ›› Issue (06): 514-517.doi: 10.3969/j.issn.1671-4091.2026.06.014

• 综述 • 上一篇    下一篇

维持性血液透析患者睡眠障碍的肠道微生物组学机制及干预研究进展

丁炳甜   孙艳艳   

  1. 030001 太原，1山西医科大学第一临床医学院 
    030001 太原，2山西医科大学第一医院肾内科
  • 收稿日期:2025-09-22 修回日期:2026-02-05 出版日期:2026-06-12 发布日期:2026-06-12
  • 通讯作者: 孙艳艳 E-mail:yanyansun6839@163.com

Recent advances in gut microbiome mechanisms underlying the sleep disorders and its intervention study in maintenance hemodialysis patients

DING Bing-tian, SUN Yan-yan   

  1. The First Clinical Medical College of Shanxi Medical University, Taiyuan 030001, China; 2Department of Nephrology, the First Hospital of Shanxi Medical University, Taiyuan 030001, China
  • Received:2025-09-22 Revised:2026-02-05 Online:2026-06-12 Published:2026-06-12
  • Contact: 030001 太原，2山西医科大学第一医院肾内科 E-mail:yanyansun6839@163.com

摘要： 血液透析患者常伴发睡眠障碍，严重影响其生活质量和临床预后。近年研究表明肠道微生物群可通过“肠-脑轴”参与睡眠调节，而维持性血液透析(maintenance hemodialysis,MHD)患者更易出现肠道微生物群失调，进而通过代谢、神经内分泌等途径影响睡眠。本文对MHD患者睡眠障碍的流行病学及微生物组学机制进行综述，评估新兴干预策略的有效性，以期为个体化治疗提供思路。
【关键词】睡眠障碍；维持性血液透析；肠道微生物；短链脂肪酸

关键词: 睡眠障碍, 维持性血液透析, 肠道微生物, 短链脂肪酸

Abstract: Sleep disorders are highly prevalent in maintenance hemodialysis (MHD) patients, which significantly impair the quality of life and clinical outcomes. Recent studies have indicated that the gut microbiota participates in sleep regulation via the "gut-brain axis", and MHD patients are more prone to present gut microbiota dysbiosis, which subsequently affects sleep through metabolic, neuroendocrine and other pathways. This review summarizes the epidemiology and microbiome mechanisms of sleep disorders in MHD patients, and evaluates the effectiveness of emerging intervention strategies, aiming to provide insights into individualized treatment.

Key words: Sleep disorders, Maintenance hemodialysis, Gut microbiota, Short-chain fatty acids

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