中国血液净化

›› 2006, Vol. 5 ›› Issue (3): 137-140.

• 论著 • 上一篇    下一篇

普伐他汀对2型糖尿病维持性血液透析患者大动脉弹性的影响

杨 飞 钟 波 王 宁 贾海英 李 莉   

  1. 100101 北京，解放军306医院血液净化中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2006-03-12 发布日期:2006-03-12

  • Received:1900-01-01 Revised:1900-01-01 Online:2006-03-12 Published:2006-03-12

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摘要： 目的 探讨普伐他汀对2型糖尿病维持性血液透析患者大动脉弹性的影响。方法 收集解放军306医院血液净化中心2型糖尿病维持血液透析患者42例，随机分成治疗组22例与对照组20例。普伐他汀剂量20mg/d口服，观察25周。测定患者总胆固醇(TC)、甘油三酯(TG)、C反应蛋白（CRP）、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)，氧化型低密度脂蛋白胆固醇（ox-LDL-C）。分别测定患者动脉脉冲速率（PWV）和踝肱指数(ABI)。结果 治疗组和对照组治疗前在年龄、血压、体重指数、TC、TG、CRP、HDL-C、LDL-C、 ox -LDL-C、PWV 和ABI差异均无显著性。治疗后，对照组PWV和ox-LDL-C水平显著增高[分别从(9.87±2.13)升至(11.36±2.37)m/s和(81.70±8.50)升到(87.90±7.80)mmol/L]。而普伐他汀治疗组PWV[从(9.41±2.31)降至(7.43±2.00)m/s] ox -LDL-C[从(89.80±5.10)降到(74.40±2.90)mmol/L]、CRP[从(1.01±0.17) 降到(0.33±0.16)mmol/l]较对照组均显著降低，差异具有显著性。结论 2型糖尿病维持性血液透析患者大动脉弹性减低，普伐他汀能改善动脉弹性，明显降低CRP水平。

关键词: 糖尿病, 血液透析, 动脉弹性, 普伐他汀

Abstract: Objective To investigate the effect of pravastatin on arterial elasticity in hemodialysis patients with type 2 diabetes. Methods Fourty-two patients with type 2 diabetes undergoing hemodialysis were randomly divided into therapy group (22 patients) and control group (22 patients). Pravastatin was administered 20mg/day for 25 weeks. total cholesteral (TC), triglyceride(TG),C-reactive protein (CRP), high density lipoprotein cholesteral (HDL-C) low density lipoprotein cholesteral (LDL-C), and oridated LDL(ox-LDL) were measured. Pulse wave velocity (PWV) and ankle brachial indexes (ABI) were detected. Results Before the therapy, there were no differences in age, blood pressure, body mass index, serum TC、TG、CRP、HDL-C、LDL-C、ox-LDL levels, PWV or ABI between therapy group and control group. After the therapy, the PWV and the serum Ox- LDL-C level increased significantly in control group [from (9.78 ±2.13) to (11.36±2.37)m/s and (81.70±8.50) to (87.9±7.80)mmol/L, respectively]. There was a significant deorease of PWV [from (9.41±2.31) to (7.43±2.00) m/s], ox-LDL [from(89.8±5.10) to (74.40±2.90) mmol/L] and CRP [from(1.01±0.17) to(0.33±0.16)mmol/L] in the therapy group. Conclusion Arterial elasticity dearease in hemodialysis patients with type 2 diabetes mellitus. Pravastatin could improve arterial elasticity and decrease serum CRP levels.

Key words: Hemodialysis, Arterial elasticity, Pravastatin

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