中国血液净化

›› 2006, Vol. 5 ›› Issue (9): 661-662.

• 论著 • 上一篇    下一篇

血液透析患者血清脂蛋白(a)与炎症、氧化应激关系研究

孟冬娅 杨 轶 罗 军 万 楠 胡晓芳 薛文成 张英辉
  

  1. 10016 沈阳，沈阳军区总医院检验科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2006-09-12 发布日期:2006-09-12

  • Received:1900-01-01 Revised:1900-01-01 Online:2006-09-12 Published:2006-09-12

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摘要： 目的 探讨血液透析患者脂蛋白(a)[Lp(a)]代谢紊乱机制，为寻找有效控制Lp(a)紊乱的方法提供理论基础。方法 收集53例透析患者、42例体检健康者空腹血清，AEROSET-2000全自动生化分析仪测定血清Lp(a)。酶联免疫吸附法(ELISA)检测氧化低密度脂蛋白(ox-LDL)、白介素-1β (IL-1β)、白介素-6(IL-6)、白介素-8(IL-8)、肿瘤坏死因子-α (TNF-α)。结果 透析组血清Lp(a)水平均显著高于对照组；透析组血清炎症相关因子IL-6、IL-8、TNF-α均显著高于对照组，IL-1β水平无显著性差异；相关性分析显示IL-6、IL-8与Lp(a)水平显著正相关。透析患者血清ox-LDL含量与对照组比差异显著，且与Lp(a)呈非常显著正相关(P ＜0.01)。结论 透析患者处于炎症、氧化应激状态可能是Lp(a)代谢紊乱且不易控制的原因之一。

关键词: 脂蛋白(a), 血液透析, 炎症因子, 氧化低密度脂蛋白

Abstract: Objective To clarify the mechanism of high levelin hemodialysis patients Lp(a) in hemodialysis patients. Methods The study was conducted on a sample of 53 chronic renal failure patients (males: 37, females: 16, age 23～75 years) who had receired hemodialysis treatment above one year. Fourty-two samples from healthy physical examination were as controls. Lp(a) level were detected by AEROSET-2000 biochemistry auto-analyzer. The quantifications of Ox-LDL, IL-1 beta, IL-6, IL-8 and TNF-alpha were performed with double-antibody ELISA. Results The serum Lp(a) levels were remarkably higher in CRF patients than in the control subjects (P ＜0.05). The serum ox-LDL IL-6 and IL-8, TNF-α levels in hemodialysis patients were remarkably higher than in the control subjects, but there were no significant difference of IL-1β level between the two groups. There were significant correlations between Lp(a) and IL-6、IL-8 and ox-LDL. Conclusions Lp(a) has comelation with inflammation and oxidative stress. It maybe one of the reasons of in creased and disordered Lp(a) level in hemodialysis patients.

Key words: Lipoprotein(a), Ox-LDL, Cytokine

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