中国血液净化

›› 2005, Vol. 4 ›› Issue (1): 19-21.

• 论著 • 上一篇    下一篇

血管紧张素转换酶抑制对维持性透析患者血浆氧化应激水平的影响

唐子勇 阿拉塔 朱 宁 何 莲 王 松 杨文领 张爱华 范敏华   

  1. 100083 北京，北京大学第三医院肾内科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2005-01-12 发布日期:2005-01-12

  • Received:1900-01-01 Revised:1900-01-01 Online:2005-01-12 Published:2005-01-12

RichHTML

0

PDF

213

摘要：

目的 观察血管紧张素转换酶抑制剂( ACEI)对维持性透析（MD）患者血浆氧化应激水平的 影响。方法 随机选取MD患者30例（血液透析20例，腹膜透析10例），加用一平苏2.5mg/日。用药之前和用药3个月后取血分离血浆。分别测定血浆丙二醛(MDA，malondialdehyde)， 晚期蛋白质氧化产物（AOPP，advanced oxidation protein product）和总抗氧化能力（total anti-oxidation capacity，T-AOC）水平。结果 参加实验的30例患者，用药前后，患者血压，血红蛋白，血浆白蛋白，透析充分性（Kt/V），和高敏C反应蛋白水平均无明显改变，总抗氧化能力无明显变化( P>0.05)。用药后，患者血浆 MDA和AOPP水平明显降低 (P<0.01)。结论 一平苏减轻维持透析患者的血浆氧化应激水平。

关键词: 血管紧张素转换酶抑制剂, 氧化应激, 血液透析, 腹膜透析

Abstract:

Objective To explore the effect of angiotensin converting enzyme inhibitor-Cilazapril on the oxidative stress of maintenance dialysis（MD）patients. Methods Thirty patients (hemodialysis 20, peritoneal dialysis 10) who had taken cilazapril 2.5 mg/d for 3 months were randomly selected. Their blood samples were taken pre and post the course. Blood MDA (malondialdehyde), AOPP (advanced oxidation protein product) and TAOC (total antioxidant capacity) were measured. Results After taken the cilazapril for three months, the patients blood pressure, hemoglobin, albumin, Kt/V, hs-CRP and TAOC did not change ( P>0.05), but the levels of MDA and AOPP in their blood decreased ( P<0.01). Conclusion Cilazapril can alleviate the oxidative stress of maintenance dialysis patients.

Key words: Oxidative Stress, Hemodialysis, Peritoneal dialysis

中图分类号: