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    Guideline on the management of hyperkalemia in maintenance hemodialysi patients in China
    Expert group of guideline on the management of hyperkalemia in maintenance hemodialysis patients in China
    Chinese Journal of Blood Purification    2022, 21 (增刊): 1-16.   DOI: 10.3969/j.issn.1671-4091.2022.S.001
    Abstract2073)      PDF(pc) (905KB)(3269)      
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    Clinical practice guideline for use of iron on anemia in chronic kidney disease
    Committee of clinical practice guideline for use of iron on anemia in chronic kidney disease
    Chinese Journal of Blood Purification    2022, 21 (增刊): 17-40.   DOI: 10.3969/j.issn.1671-4091.2022.S.002
    Abstract1170)      PDF(pc) (1508KB)(3057)      
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    Chinese Journal of Blood Purification    2019, 18 (07): 442-472.   DOI: 10.3969/j.issn.1671-4091.2019.07.002
    Abstract883)      PDF(pc) (731KB)(3069)      
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    The new classification of uremic toxins
    LI Chao, WEI Tao
    Chinese Journal of Blood Purification    2023, 22 (11): 801-805,815.   DOI: 10.3969/j.issn.1671-4091.2023.11.001
    Abstract362)      PDF(pc) (521KB)(697)      
    ?The retention and increase of uremic toxin will lead to a series of uremic symptoms, which will affect many systems of the whole body, and lead to the decline of patients' quality of life and high mortality. In 2003, the European Uremic Working Group classified uremic toxins into three groups according to their physical chemistry properties: water-soluble small molecule compounds, protein-binding compounds, and middle molecule compounds. With the new understanding of uremic solutes, the new data of sources and the development of hemodialysis methods and membrane materials, the previous classification can not fully adapt to the new progress in the field of blood purification. Accordingly, in november-december 2020, Claudio R, as president of the General Assembly, convened an expert meeting and prepared an expert consensus that provided new insights into the definition and classification of uremic toxin  tails the expert group's consensus recommendations for new definitions and more clinically oriented new classifications of uremic toxins.
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    Investigation on anemia risk of non dialysis chronic kidney disease patients in China (INSIGHT study)
    National anemia investigation working group of chronic non dialysis renal disease patients
    Chinese Journal of Blood Purification    2022, 21 (增刊): 53-69.   DOI: 10.3969/j.issn.1671-4091.2022.S.004
    Abstract319)      PDF(pc) (609KB)(1206)      
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    Chinese Journal of Blood Purification    2022, 21 (01): 59-62.   DOI: 10.3969/j.issn.1671-4091.2022.01.014
    Abstract458)      PDF(pc) (448KB)(2580)      
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    null    2011, 10 (7): 386-389.  
    Abstract325)   HTML0)    PDF(pc) (176KB)(1110)      
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    The clinical significance of transmembrane pressure monitoring in hemodialysis
    Chinese Journal of Blood Purification    2018, 17 (07): 490-493.   DOI: 10.3969/j.issn.1671-4091.2018.07.015
    Abstract626)      PDF(pc) (396KB)(1755)      
    【Abstract】This paper analyzes the causes of transmembrane pressure change and its unfavorable effects. We focuse on the principle of transmembrane pressure monitoring in dialysis machine. We particularly emphasize the training for medical staffs about the importance of transmembrane pressure monitoring and the manipulation of relevant preventive measures to achieve safe and efficient use of dialysis.
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    Syphilis Laboratory Tests and Interpretation of Results
    Chinese Journal of Blood Purification    2017, 16 (10): 661-663.   DOI: 10.3969/j.issn.1671-4091.2017.010.005
    Abstract395)      PDF(pc) (298KB)(2036)      
    The incidence of syphilis has gradually increased in recent years, laboratory test is important for the correct diagnosis of syphilis .This paper has reviewed the clinical characteristics and laboratory test progress in syphilis diagnosis, especially in Nontreponemal tests and treponemal tests for syphilis infection diagnosis
    and laboratory test results interpretation for clinical use.
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    A review of factorial and risk analysis for hyperkalemia in hemodialysis patients
    Chinese Journal of Blood Purification    2022, 21 (03): 149-152.   DOI: 10.3969/j.issn.1671-4091.2022.03.002
    Abstract412)      PDF(pc) (397KB)(807)      
    【Abstract】Patients with end-stage renal disease (ESRD) on maintenance hemodialysis have a high incidence of hyperkalemia, and with the deterioration of renal function, the risk of recurrence of hyperkalemia gradually increases. Many factors, including inappropriate dialysis, concomitant use of drugs that raise serum potassium, and certain medical conditions, increase the risk of hyperkalemia in dialysis patients. Hyperkalemia in dialysis patients is closely related to its poor prognosis, not only increasing the risk of death, but also increasing the number of emergency department visits and hospitalizations, and medical costs. Therefore, for HD patients with recurrent hyperkalemia, attention should be paid to the comprehensive management of serum potassium levels, including restriction of high potassium diet, adequate dialysis treatment, avoidance of drugs that increase serum potassium, and rational use of potassium-lowering drugs.
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    Application of anti-Xa factor activity assay in low molecular weight heparin anticoagulation in hemodialysis patients 
    WANG Zhen-xing, XU Leng-nan, FU Pei-jie, DANG Xin, MAO Yong-hui
    Chinese Journal of Blood Purification    2022, 21 (05): 365-368.   DOI: 10.3969/j.issn.1671-4091.2022.05.014
    Abstract796)      PDF(pc) (398KB)(777)      
    Low molecular weight heparin (LMWH) is one of the commonly used anticoagulants. Its anticoagulation effect and bleeding risk are often monitored by the anti-Xa factor activity. Appropriate anti-Xa factor activity range is also recommended in clinical guidelines. As for hemodialysis patients using LMWH, there is no consensus about the target range of anti-Xa factor activity. This review mainly discusses the value of anti-Xa factor activity assay in LMWH anticoagulation for hemodialysis and the recent progresses in its specific monitoring strategies.
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    Research and Application Progress of Long acting Erythropoietin
    LIU Ai-chun, WEI Tao
    Chinese Journal of Blood Purification    2023, 22 (03): 161-163.   DOI: 10.3969/j.issn.1671-4091.2023.03.001
    Abstract327)      PDF(pc) (342KB)(789)      
    China has a large number of patients with renal anemia and tumor anemia after radiotherapy and chemotherapy. Long acting erythropoietin (EPO) has the advantages of long half-life and high biological activity. It can reduce the frequency and dose of administration, improve patient compliance and improve the effect of anemia treatment. This paper summarizes the design scheme, advantages and application prospects of long-acting EPO in order to provide a theoretical basis for promoting the wide application of long-acting EPO in China.
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    Role of Ferrostatin-1 prevent high glucose-induced Ferroptosis of renal tubular epithelial cells
    WU Zi-yu, LIN Yan, LIANG Yuan-qi, GUO Tai-lin
    Chinese Journal of Blood Purification    2023, 22 (09): 679-684.   DOI: 10.3969/j.issn.1671-4091.2023.09.010
    Abstract111)      PDF(pc) (774KB)(523)      
    Objective To investigate the role of Ferrostatin-1(Fer-1) in high glucose-induced ferroptosis of renal tubular epithelial cells. Method (1) 24 DBA/2J mice were randomly divided into 4 groups: normal control group, Fer-1 intervention group, DM model group, DM + Fer-1 intervention group with 6 mice in each group. According to the body weight of mice, DBA/2J mice were injected intraperitoneally with freshly prepared Streptozocin at a dose of 40 mg / kg for 5 days to establish DM model. Fer-1 intervention group and DM+Fer-1 intervention group were given intraperitoneal injection of Fer-1 (2.5μmol/kg) every day for 12 weeks after modeling.. The control group and DM Group were intraperitoneally injected with the same volume of normal saline for 12 weeks. The expression levels of activated glutathione peroxidase 4(GPX4)and solute carrier family 7 A11(SLC7A11)were detected by Western blotting, and the expression and localization of GPX4 in renal tissue were detected by immunohistochemistry.(2) Human renal tubular epithelial cells (HK-2) were stimulated with high glucose (30 mmol/L) , and treated with 200 nm Fer-1. The expression of ferroptosis signaling in renal tubular epithelial cells was detected by Western blotting and immunofluorescence staining. Results  Compared with the normal control group, the levels of Fe2+and Malondialdehyde (MDA) in the kidney of DM model group were significantly up-regulated, glutathione (GSH) was significantly down-regulated ( t=35.073、15.732 and 4.954 respectively,all P < 0.001) , and the protein expression levels of GPX4 and SLC7A11, which were related to ferroptosis, were significantly up-regulated (t=12.432 and 5.484;P=0.006 and 0.003) . Compared with the DM model group, the levels of Fe2+ and MDA in the kidney of DM +Fer-1 intervention group were down-regulated, while GSH was up-regulated (t=14.503、4.675 and 7.124; all P<0.001) . The protein expression levels of GPX4 and SLC7A11 were up-regulated (t =4.573 and 27.942;P= 0.039 and 0.001) . In addition, high glucose could induce the expression levels of ferroptosis related proteins GPX4 and SLC7A11 in HK-2 cells cultured in vitro to decrease significantly ( t=12.433 and 7.716;P=0.006 and 0.019) , the expression levels of GPX4 and SLC7A11 were significantly increased by Fer-1(t=5.136 and 5.043;P=0.035 and 0.037) . Conclusions  Inhibition of ferroptosis in renal tubular epithelial cells induced by high glucose may be a new strategy to prevent the progression of DM.
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    null    2008, 7 (7): 399-402.  
    Abstract550)   HTML1)    PDF(pc) (487KB)(2384)      
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    Interpretation on the clinical practice guidelines and expert consensus about exercise rehabilitation in chronic kidney disease
    Chinese Journal of Blood Purification    2022, 21 (02): 111-114.   DOI: 10.3969/j.issn.1671-4091.2022.02.010
    Abstract438)      PDF(pc) (406KB)(1219)      
    【Abstract】Physical activity and exercise have been recognized gradually as“medicine”for the management of chronic kidney disease. On April 8, 2021, British Renal Society published the“Clinical Practice Guideline: Exercise and Lifestyle in Chronic Kidney Disease”, which provides guidance on physical activity/exercise, weight management, and other lifestyle consideration in non-dialysis chronic kidney disease, hemodialysis and kidney transplant recipients. This paper interprets the module of physical activity/exercise combined with the consensus of experts in our country.
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    The technical issues in clinical application of plasma exchange
    Chinese Journal of Blood Purification    2021, 20 (05): 289-293.   DOI: 10.3969/j.issn.1671-4091.2021.05.001
    Abstract722)      PDF(pc) (437KB)(1867)      
    【Abstract】Plasma exchange (PE) is a blood purification method aiming at removing circulating pathogenic proteins or protein-bound substances, which has been widely applied in treating various diseases, including autoimmune diseases. It has two technical forms: membrane separation(MPE) and centrifugal separation (CPE). The technical issues include prescription of treatment dose and frequency, choice of plasma separator, setup of treatment parameters including blood flow rate, plasma separation rate, choice of replacement fluid, anticoagulation, prevention of clinical and technical complications. In this paper, we reviewed all of the issues mentioned above in detail.
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    Comparison of the advantages and disadvantages of several continuous renal replacement therapy technologies
    Chinese Journal of Blood Purification    2021, 20 (12): 801-804.   DOI: 10.3969/j.issn.1671-4091.2021.12.003
    Abstract676)      PDF(pc) (469KB)(1094)      
    【Abstract】Continuous renal replacement therapy (CRRT) has the roles of ultrafiltration to remove excess water, convection to clear medium and small molecular solutes, and adsorption to eliminate inflammatory mediators. The therapeutic models of CRRT are developed progressively, such as continuous venous-venous hemofiltration (CVVH), continuous venous- venous hemodiafiltration (CVVHDF), high- volume hemofiltration (HVHF), continuous plasma filtration adsorption (CPFA), and slow continuous ultrafiltration (SCUF). CVVH is the most commonly used model, usually as an adjuvant method for refractory heart failure, severe acute pancreatitis, rhabdomyolysis, and many others; CVVHDF has been widely used for the treatment of sepsis;
    HVHF is a treatment often for severe sepsis and septic shock; CPFA can be used in severe inflammatory response syndrome and sepsis; SCUF is often used in patients with refractory heart failure, edema, and overload of extracellular fluid volume. Every CRRT technology has its own characteristics, and the selection of therapeutic model and dosage must be individualized based on clinical situation of the patient.
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    null    2007, 6 (11): 610-613.  
    Abstract348)   HTML0)    PDF(pc) (266KB)(1452)      
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    Effects of different dialysate potassium concentration on serum potassium and arrhythmia during hemodialysis
    Chinese Journal of Blood Purification    2014, 13 (04): 298-301.   DOI: 10.3969/j.issn.1671-4091.2014.04.002
    Abstract288)   HTML0)    PDF(pc) (407KB)(925)      
    0bjective To investigate the effect of dialysate potassium concentration (KD) on predialysis serum potassium and the incidence of hyperkalemia or arrhythmia during hemodialysis.Methods A single-center, open, self-controlled trial was conducted and patients were enrolled according to certain criteria. Predialysis serum potassium was examined when KD=2.0mmol/L (KD 2.0, the following was similar) was still used at one week in May 2010 (0 point). And then KD 2.5 was applied. Predialysis serum potassium was examined in 2, 4, 8, 12 weeks later, respectively. Serious arrhythmic events during hemodialysis were recorded in 12 weeks before and after 0 point.Results 158 patients were enrolled, 2 cases were exit and 156 cases were analyzed. Compared to KD 2.0, KD 2.5 could decrease the incidence of serious arrhythmia during hemodialysis, but the decline had not statistically significant difference (0.78% VS 0.47%,P=0.054).Predialysis mean serum potassium, incidence of hyperkalemia and severe hyperkalemia were significantly increased in 2 weeks after KD 2.5 applied (4.51±0.79 VS 4.78±0.80 mmol/L, 15.4% VS 26.9%, 3.2% VS 9.6%,P<0.05, respectively). After intervention for 10 weeks, the incidence of hyperkalemia dropped to the level of 0 point, although predialysis mean serum potassium was still significantly higher. Conclusions Compared to KD 2.0, KD 2.5 had the trends to decrease the incidence of serious arrhythmia during hemodialysis, but increased predialysis hyperkalemia which can be controlled through clinical intervention.
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    Recent progress in urgent-start peritoneal dialysis
    Chinese Journal of Blood Purification    2020, 19 (07): 433-436.   DOI: 10.3969/j.issn.1671-4091.2020.07.001
    Abstract450)      PDF(pc) (367KB)(1585)      
    【Abstract】End stage renal disease (ESRD) has become an important public health problem worldwide. The insidious progress of ESRD often leads to the requirement of urgent-start dialysis when admitted to hospitals. Currently, hemodialysis with central vein catheterization is still the most commonly used method of urgent-start dialysis. However, this method has the risks of catheter- related infection, bacteremia, thrombosis and other complications with higher medical expenses. Due to the continuous progress of automated peritoneal dialysis technology, the interest to urgent-start peritoneal dialysis(PD) increases in recent years. Most studies show that urgent-start PD is safe, effective, favorable to health economics, and worthy of widely used.
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    Epidemiological analysis of the maintenance hemodialysis patients over the past 5 years
    Chinese Journal of Blood Purification    2015, 14 (11): 698-702.   DOI: 10.3969/j.issn.1671-4091.2015.11.015
    Abstract620)   HTML14)    PDF(pc) (475KB)(1686)      
    【Abstract】Objective To obtain the data supporting standardized treatment and continuously improving the quality of hemodialysis, we investigated the current treatment status and epidemiology of maintenance hemodialysis (MHD) patients in our hemodialysis center. Methods We retrospectively reviewed the clinical records of 513 MHD patients treated for more than 3 months in the Blood Purification Center, the Second Hospital of Shanxi Medical University between Jan. 2010 and Dec. 2014. Gender, onset age, medical expense type, primary renal disease, the first vascular access type, complications, changes of treatment, cause of death, and survival rate were analyzed. All related data were collected through the Chinese National Renal Data System. Results ①In our hemodialysis center, the number of hemodialysis patients increased annually. Among the 513 MHD patients, 291 were males and 222 were females with a male/female ratio of 1.3 to 1. ②Most patients with end stage renal disease (ESRD) were in the age of 40 to 49 years and 50 to 59 years. ③In the 431 patients with defined causes of ESRD, the top 3 primary causes were glomerulonephritis (48.0%), diabetic nephropathy (25.9%), and hypertensive nephrosclerosis (10.7%). ④The first used vascular access at the beginning of hemodialysis was temporary central venous catheter (76.8% ), and primary arteriovenous fistula (21.5%). ⑤Anemia was the most common complication, followed by hypertension, bone and mineral disorders. The rates achieved to the recommended levels of hemoglobin, blood pressure, blood calcium, blood phosphorus and IPTH were less than 50%. ⑥Among 513 MHD patients, 12 received renal transplantation, 11 changed to peritoneal dialysis, 385 transferred to other hospitals for hemodialysis, 5 got rid of dialysis, 9 gave up the treatment, 24 died, and 67 were still hospitalized in our unit. Cardiovascular and cerebrovascular incidences were the leading causes of death. ⑦The survival rate of MHD patients was different: 93.3% in one
    year, 75.3% in five years, 14.6% in ten years, and one for more than 228 months and still under regular dialysis. Conclusion In our dialysis center, the majority of the MHD patients were middle aged and elderly males. The first three primary causes leading to ESRD were glomerulonephritis, diabetic nephropathy, and hypertensive nephrosclerosis. The major vascular access at the beginning of hemodialysis was temporary central venous catheter, suggesting that timely hemodialysis should be emphasized. The incidence rate of anemia, hypertension, bone and mineral disorders were high, but the control rates were low. Cardiovascular and cerebrovascular incidences were the leading cause of death. As the hemodialysis treatment was prolonged, the longterm survival rate of MHD patients was gradually reduced.
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    Summary of the best evidence for central venous catheterization in hemodialysis patients
    Chinese Journal of Blood Purification    2020, 19 (08): 569-572.   DOI: 10.3969/j.issn.1671-4091.2020.08.017
    Abstract431)      PDF(pc) (390KB)(1418)      
    【Abstract】Objective To retrieve, evaluate and integrate the best evidence for central venous catheterization in hemodialysis patients, and to summarize the best evidence. Methods A computer search of the Cochrane Library, PubMed, Embase, Medline, Wanfang, China Knowledge Network, Weipu and other databases and Yimaitong Clinical Guide Network, JBI EvidencEbased Nursing Database and Chinese database CNKI was performed. The searched evidence and results of randomized controlled experiments were summarized. The search period was from the time of construction to March 1, 2020. Results A total of 10 articles were enrolled, including 2 guidelines, 3 systematic reviews, 1 expert consensus, and 4 randomized controlled trials. Conclusion The best evidence of central venous catheterization for hemodialysis patients was summarized and specific recommendations were formed, which provide evidencEbased nursing for clinical medical staff, and instructive significance for scientific nursing of central venous catheterization in hemodialysis patients.
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    null    2005, 4 (11): 581-584.  
    Abstract404)   HTML4)    PDF(pc) (293KB)(1569)      
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    A comparative study of two different types of dialysis machines
    Chinese Journal of Blood Purification    2019, 18 (11): 801-804.   DOI: 10.3969/j.issn.1671-4091.2019.11.019
    Abstract758)      PDF(pc) (657KB)(1306)      
    【Abstract】Objective To compare the cleanliness and failure rate between the dialysis machines with central dialysis fluid delivery (CDDS) system and the conventional dialysis machines, and to analyze the clinical application advantages of the dialysis machines with CDDS system. Methods From August 2017 to March 2018, the bacteria number and endotoxin level at the inlet and outlet sites were compared between the dialysis machines with CDDS system (5 sets) and the Berengdejia dialyzer (5 sets) in the PLA General Hospital Dialysis Center. A retrospective analysis was performed on the incidence of water, circuit and other faults occurred in the dialysis machines with CDDS system (18 sets) and the Berengdejia dialyzer (18 sets) during the period from March 2017 to March 2019. Results The bacteria number and endotoxin level at the inlet were lower in the dialysis machines with CDDS system than in the conventional dialysis machines (t=11.215 and 6.468 respectively; P<0.001). The bacteria number and endotoxin level at the outlet were also lower in the dialysis machines with CDDS system than in the conventional dialysis machines (t=9.154 and 5.490 respectively; P<0.001). The incidence of water, circuit and other faults were lower in the dialysis machines with CDDS system than in the conventional dialysis machines (t=9.147, P=0.010). Conclusion CDDS system can improve the cleanliness of dialysate and reduce the failure rate of dialysis machines during clinical applicati
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    Chinese Journal of Blood Purification    2014, 13 (10): 729-732.   DOI: 10.3969/j.issn.1671-4091.2014.10.013
    Abstract480)   HTML19)    PDF(pc) (284KB)(4084)      
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    Chinese Journal of Blood Purification    2016, 15 (04): 244-246.   DOI: 10.3969/j.issn.1671-4091.2016.04.013
    Abstract227)   HTML1)    PDF(pc) (248KB)(874)      
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    Long-term survival analysis of maintenance hemodialysis patients
    Chinese Journal of Blood Purification    2019, 18 (12): 826-829.   DOI: 10.3969/j.issn.1671-4091.2019.12.005
    Abstract643)      PDF(pc) (374KB)(1467)      
    【Abstract】Objective Through the analysis of multiple related factors in maintenance hemodialysis (MHD) patients in a single center, the factors affecting long-term survival were evaluated for the improvement of survival rate and quality of life in MHD patients. Methods We retrospectively analyzed clinical records of 235 patients treated with MHD for more than 3 months in the Blood Purification Center, the Second Hospital of Shanxi Medical University between January 2010 and December 2017 to explore the impact of related factors on survival of MHD patients. Results Among the 235 MHD patients, 133 were males and 102 were females. The survival rate was 93.7% in one year, 81.4% in three years, 76.2% in five years and 16.4% in ten years. The longest survival patient lasted MHD for 252 months and still survived well. Older age at the first dialysis (RR=1.03, P<0.001), diabetic nephropathy (RR=2.24, P<0.001), dialysis frequency <2 times per week (RR=2.34, P<0.001) and higher blood phosphorus before dialysis (RR=1.34, P<0.001) increased the risk of death in MHD patients. Autologous arteriovenous fistula beginning from the first vascular access (RR=0.78, P<0.001), urea clearance index (Kt/V) >1.2 (RR=0.72, P<0.001) and higher hemoglobin (RR=0.76, P< 0.001) and albumin levels (RR=0.61, P<0.001) decreased the risk of death in MHD patients. Conclusion As the hemodialysis treatment prolonged, the long-term survival rate declined gradually. Older age at the first dialysis, diabetic nephropathy and high levels of blood phosphorus before dialysis were the risk factors for survival. Autologous arteriovenous fistula used earlier, better dialysis adequacy and higher hemoglobin and albumin levels were the protection factors for survival in MHD patients.
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    The research progress of nutritional therapy for chronic kidney disease
    Chinese Journal of Blood Purification    2020, 19 (04): 259-262.   DOI: 10.3969/j.issn.1671-4091.2020.04.013
    Abstract345)      PDF(pc) (310KB)(1792)      
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    Home hemodialysis machine technology: a global overview
    Chinese Journal of Blood Purification    2022, 21 (02): 73-76.   DOI: 10.3969/j.issn.1671-4091.2022.02.001
    Abstract708)      PDF(pc) (1299KB)(881)      
    【Abstract】At present, there are only few cases of home hemodialysis in Chinese mainland, and the machines uses are traditional dialysis machine. In Europe and America, most home hemodialysis patients use the machines specially designed for home dialysis, which are more compact and easy to operate. This paper will briefly describe the home dialysis machine and related technologies that have been used abroad.
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    Chinese Journal of Blood Purification    2021, 20 (11): 721-727.   DOI: 10.3969/j.issn.1671-4091.2021.11.001
    Abstract951)      PDF(pc) (395KB)(1284)    PDF(mobile) (395KB)(49)   
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    null    2006, 5 (11): 792-794.  
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    Chinese Journal of Blood Purification    2018, 17 (02): 129-132.   DOI: 10.3969/j.issn.1671-4091.2018.02.013
    Abstract425)      PDF(pc) (317KB)(1131)      
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    Chinese Journal of Blood Purification    2020, 19 (05): 353-356.   DOI: 10.3969/j.issn.1671-4091.2020.05.018
    Abstract246)      PDF(pc) (258KB)(1484)      
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    Research updates on hyperphosphatemia in Chronic kidney disease
    CHENYa-fei, ZUOL
    Chinese Journal of Blood Purification    2022, 21 (05): 305-308.   DOI: 10.3969/j.issn.1671-4091.2022.05.001
    Abstract705)      PDF(pc) (383KB)(1066)      
    Chronic kidney disease (CKD) is highly prevalent in general population. With the decline of kidney function, the abnormality of phosphorus metabolism is gradually aggravated. In China, hyperphosphatemia in CKD is characterized by high prevalence and low control rate. Hyperphosphatemia is an independent risk factor of CKD progression, secondary hyperparathyroidism, cardiovascular events, and all-cause mortality in CKD patients. Literatures on mechanisms of hyperphosphatemia and its adverse outcomes were reviewed.
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    Progress in the study of complications of renal anemia
    WANG Zeng, ZHANG Yang, WANG Qin, ZHU Qi- fan, CHEN Hong- yu
    Chinese Journal of Blood Purification    2022, 21 (07): 469-472.   DOI: doi:10.3969/j.issn.1671-4091.2022.07.002
    Abstract104)      PDF(pc) (400KB)(581)      
    Renal anemia is one of the common symptoms of most patients with chronic kidney disease (CKD). Renal anemia will bring many complications, including cardiovascular disease, inflammatory state, and gastrointestinal bleeding, etc. In clinical correction of renal anemia, the treatment of complications should also be taken into account. This article reviews the literature on the mechanism and treatment of renal anemia complications for clinical reference.
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    The erasons of A-V fictula plug and the care measures in maintain hemodialysis patients
    Chinese Journal of Blood Purification    2013, 12 (10): 576-578.  
    Abstract292)   HTML4)    PDF(pc) (293KB)(1336)      
    【Abstract】: Objective Purpose:Analysising the reasons of A-V fistula plug in maintain hemodialysis patients and then to improve the care measures. Methods: Retrospective analysis the hemodialysis records of 109 patients in our hospital from Jan. 2011 to Dec. 2011. Results:There were 10 patients occurring A-V fistula plug(9.17%).Bad vascular conditions were 2,excessive ultrafiltration were 4,repeated fixed-point puncture were 3,and oppression improper was 1 of them all. Conclusion:Inappropriate care may cause the A-V fistula plug.
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    Effects of the active form vitamin D on metabolism and kidney cell function in patients with chronic kidney disease
    GUO Zi-Yi, ZHANG Zi-yuan, FANG Jing-ai
    Chinese Journal of Blood Purification    2024, 23 (04): 286-289.   DOI: 10.3969/j.issn.1671-4091.2024.04.010
    Abstract120)      PDF(pc) (472KB)(205)      
    Vitamin D is a lipid-soluble steroid derivative. Insufficiency or deficiency of vitamin D in patients with chronic kidney disease (CKD) affects calcium-phosphorus homeostasis, parathyroid hormone (PTH) level and glucose and lipid metabolism, leading to the presence of a series of complications, lower quality of life and reduced survival rate in CKD patients. This article reviews the mechanism of vitamin D on metabolism and kidney cell function in CKD patients to provide bases for the prevention and treatment of CKD and its complications.
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    Recent progresses in the pathogenesis of pruritus in maintenance hemodialysis patients
    Chinese Journal of Blood Purification    2021, 20 (01): 43-46.   DOI: 10.3969/j.issn.1671-4091.2021.01.10
    Abstract520)      PDF(pc) (411KB)(1738)      
    【Abstract】skin pruritus is a common symptom in end-stage renal disease patients undergoing maintenance hemodialysis (MHD). Pruritus affects the quality of life, causes anxiety, depression, sleep disorders, and unfavorable prognosis of the patients. Although many kinds of treatment can be used clinically, the curative effect is limited. The pathogenesis of pruritus is complicated. This paper expounds the pathogenesis of skin pruritus in MHD patients from the perspectives of dry skin, immune inflammation hypothesis, histamine, bivalent ions, opioid hypothesis, parathyroid hormone, peripheral neuropathy, dialysis adequacy and mode, and glycosylation hypothesis.
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    Chinese Journal of Blood Purification    2013, 12 (03): 156-158.  
    Abstract152)   HTML0)    PDF(pc) (167KB)(1293)      
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    Chinese Journal of Blood Purification    2021, 20 (06): 395-397.   DOI: 10.3969/j.issn.1671-4091.2021.06.009
    Abstract280)      PDF(pc) (257KB)(1208)      
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