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    Guideline on the management of hyperkalemia in maintenance hemodialysi patients in China
    Expert group of guideline on the management of hyperkalemia in maintenance hemodialysis patients in China
    Chinese Journal of Blood Purification    2022, 21 (增刊): 1-16.   DOI: 10.3969/j.issn.1671-4091.2022.S.001
    Abstract2073)      PDF(pc) (905KB)(3269)      
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    Chinese Journal of Blood Purification    2022, 21 (01): 59-62.   DOI: 10.3969/j.issn.1671-4091.2022.01.014
    Abstract458)      PDF(pc) (448KB)(2580)      
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    Clinical practice guideline for use of iron on anemia in chronic kidney disease
    Committee of clinical practice guideline for use of iron on anemia in chronic kidney disease
    Chinese Journal of Blood Purification    2022, 21 (增刊): 17-40.   DOI: 10.3969/j.issn.1671-4091.2022.S.002
    Abstract1170)      PDF(pc) (1508KB)(3057)      
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    Chinese Journal of Blood Purification    2019, 18 (07): 442-472.   DOI: 10.3969/j.issn.1671-4091.2019.07.002
    Abstract883)      PDF(pc) (731KB)(3069)      
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    Syphilis Laboratory Tests and Interpretation of Results
    Chinese Journal of Blood Purification    2017, 16 (10): 661-663.   DOI: 10.3969/j.issn.1671-4091.2017.010.005
    Abstract395)      PDF(pc) (298KB)(2036)      
    The incidence of syphilis has gradually increased in recent years, laboratory test is important for the correct diagnosis of syphilis .This paper has reviewed the clinical characteristics and laboratory test progress in syphilis diagnosis, especially in Nontreponemal tests and treponemal tests for syphilis infection diagnosis
    and laboratory test results interpretation for clinical use.
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    null    2007, 6 (11): 610-613.  
    Abstract348)   HTML0)    PDF(pc) (266KB)(1452)      
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    null    2008, 7 (7): 399-402.  
    Abstract550)   HTML1)    PDF(pc) (487KB)(2385)      
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    Chinese Journal of Blood Purification    2014, 13 (10): 729-732.   DOI: 10.3969/j.issn.1671-4091.2014.10.013
    Abstract480)   HTML19)    PDF(pc) (284KB)(4084)      
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    Interpretation on the clinical practice guidelines and expert consensus about exercise rehabilitation in chronic kidney disease
    Chinese Journal of Blood Purification    2022, 21 (02): 111-114.   DOI: 10.3969/j.issn.1671-4091.2022.02.010
    Abstract438)      PDF(pc) (406KB)(1219)      
    【Abstract】Physical activity and exercise have been recognized gradually as“medicine”for the management of chronic kidney disease. On April 8, 2021, British Renal Society published the“Clinical Practice Guideline: Exercise and Lifestyle in Chronic Kidney Disease”, which provides guidance on physical activity/exercise, weight management, and other lifestyle consideration in non-dialysis chronic kidney disease, hemodialysis and kidney transplant recipients. This paper interprets the module of physical activity/exercise combined with the consensus of experts in our country.
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    null    2005, 4 (11): 581-584.  
    Abstract404)   HTML4)    PDF(pc) (293KB)(1569)      
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    Investigation on anemia risk of non dialysis chronic kidney disease patients in China (INSIGHT study)
    National anemia investigation working group of chronic non dialysis renal disease patients
    Chinese Journal of Blood Purification    2022, 21 (增刊): 53-69.   DOI: 10.3969/j.issn.1671-4091.2022.S.004
    Abstract319)      PDF(pc) (609KB)(1206)      
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    Review of the guidelines and consensus about the treatment of renal anemia
    Chinese Journal of Blood Purification    2018, 17 (01): 1-5.   DOI: 10.3969/j.issn.1671-4091.2018.01.001
    Abstract728)      PDF(pc) (412KB)(1518)      
    Anemia is one of the common complications in chronic kidney disease patients. The standardized treatment of renal anemia relates to anemia monitoring, rational use of iron and erythropoietin, anemia treatment targets, etc. The guidelines and consensus are highly significant to renal anemia treatment. We aim
    to provide clinicians with the advices through reassessment of the guidelines in EBPGs, K/DOQI, K/DIGO and NICE.
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    Epidemiological analysis of the maintenance hemodialysis patients over the past 5 years
    Chinese Journal of Blood Purification    2015, 14 (11): 698-702.   DOI: 10.3969/j.issn.1671-4091.2015.11.015
    Abstract620)   HTML14)    PDF(pc) (475KB)(1686)      
    【Abstract】Objective To obtain the data supporting standardized treatment and continuously improving the quality of hemodialysis, we investigated the current treatment status and epidemiology of maintenance hemodialysis (MHD) patients in our hemodialysis center. Methods We retrospectively reviewed the clinical records of 513 MHD patients treated for more than 3 months in the Blood Purification Center, the Second Hospital of Shanxi Medical University between Jan. 2010 and Dec. 2014. Gender, onset age, medical expense type, primary renal disease, the first vascular access type, complications, changes of treatment, cause of death, and survival rate were analyzed. All related data were collected through the Chinese National Renal Data System. Results ①In our hemodialysis center, the number of hemodialysis patients increased annually. Among the 513 MHD patients, 291 were males and 222 were females with a male/female ratio of 1.3 to 1. ②Most patients with end stage renal disease (ESRD) were in the age of 40 to 49 years and 50 to 59 years. ③In the 431 patients with defined causes of ESRD, the top 3 primary causes were glomerulonephritis (48.0%), diabetic nephropathy (25.9%), and hypertensive nephrosclerosis (10.7%). ④The first used vascular access at the beginning of hemodialysis was temporary central venous catheter (76.8% ), and primary arteriovenous fistula (21.5%). ⑤Anemia was the most common complication, followed by hypertension, bone and mineral disorders. The rates achieved to the recommended levels of hemoglobin, blood pressure, blood calcium, blood phosphorus and IPTH were less than 50%. ⑥Among 513 MHD patients, 12 received renal transplantation, 11 changed to peritoneal dialysis, 385 transferred to other hospitals for hemodialysis, 5 got rid of dialysis, 9 gave up the treatment, 24 died, and 67 were still hospitalized in our unit. Cardiovascular and cerebrovascular incidences were the leading causes of death. ⑦The survival rate of MHD patients was different: 93.3% in one
    year, 75.3% in five years, 14.6% in ten years, and one for more than 228 months and still under regular dialysis. Conclusion In our dialysis center, the majority of the MHD patients were middle aged and elderly males. The first three primary causes leading to ESRD were glomerulonephritis, diabetic nephropathy, and hypertensive nephrosclerosis. The major vascular access at the beginning of hemodialysis was temporary central venous catheter, suggesting that timely hemodialysis should be emphasized. The incidence rate of anemia, hypertension, bone and mineral disorders were high, but the control rates were low. Cardiovascular and cerebrovascular incidences were the leading cause of death. As the hemodialysis treatment was prolonged, the longterm survival rate of MHD patients was gradually reduced.
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    Measurement method of renal uric acid excretion ability in patients with hyperuricemia 
    LIU Yue, WANG Yue
    Chinese Journal of Blood Purification    2023, 22 (05): 381-383.   DOI: 10.3969/j.issn.1671-4091.2023.05.014
    Abstract139)      PDF(pc) (341KB)(876)      
    About 90% of the hyperuricemia patients are found to have renal dysfunction of uric acid excretion. Guidelines and consensus from China and foreign countries have recommend that the 24-hour uric acid excretion fraction and/or 24-hour uric acid excretion can be used for assay of renal uric acid excretion ability, clinical classification and drug selection. However, collection of a 24-hour urine sample takes a long time, and the result may not be accurate due to the possible contamination and incomplete sampling during collection and limited urine storage condition. Previous studies have found that uric acid excretion fraction in random urine sample, especially in morning urine sample, is a simple and efficient method, which may replace the 24-hour uric acid excretion method to evaluate renal uric acid excretion function and to guide clinical classification and treatment in hyperuricemia patients.
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    null    2008, 7 (11): 618-621.  
    Abstract516)   HTML2)    PDF(pc) (292KB)(2391)      
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    The research progress of nutritional therapy for chronic kidney disease
    Chinese Journal of Blood Purification    2020, 19 (04): 259-262.   DOI: 10.3969/j.issn.1671-4091.2020.04.013
    Abstract345)      PDF(pc) (310KB)(1792)      
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    A review of iron metabolism, laboratory assessment and strategy for iron management
    Chinese Journal of Blood Purification    2020, 19 (03): 157-160.   DOI: 10.3969/j.issn.1671-4091.2020.03.004
    Abstract528)      PDF(pc) (414KB)(1935)      
    【Abstract】Iron is a vital trace element for humans. The amount of iron in the body has to be maintained in an ideal range. The absorption of dietary iron and the transport of iron are complex processes critical for iron homeostasis. The reticuloendothelial system is responsible for iron recycling through phagocytosis of the erythrocytes. Hepcidin is a liver-derived peptide hormone and an important regulator of iron metabolism. This hormone acts in many target tissues and regulates iron level in the body through a negative feedback mechanism. Serum ferritin is a fundamental index to reflec iron metabolism situation in the body. In chronic inflammatory conditions, higher thresholds of ferritin concentration and transferrin saturation, and other laboratory examinations such as soluble and serum transferrin receptors and hepcidin are required for the evaluation of this disease conditions. The best evidences and experiences should be referred in the determination of the iron supplementation strategy for iron deficiency in inflammation and chronic kidney disease.
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    The technical issues in clinical application of plasma exchange
    Chinese Journal of Blood Purification    2021, 20 (05): 289-293.   DOI: 10.3969/j.issn.1671-4091.2021.05.001
    Abstract722)      PDF(pc) (437KB)(1867)      
    【Abstract】Plasma exchange (PE) is a blood purification method aiming at removing circulating pathogenic proteins or protein-bound substances, which has been widely applied in treating various diseases, including autoimmune diseases. It has two technical forms: membrane separation(MPE) and centrifugal separation (CPE). The technical issues include prescription of treatment dose and frequency, choice of plasma separator, setup of treatment parameters including blood flow rate, plasma separation rate, choice of replacement fluid, anticoagulation, prevention of clinical and technical complications. In this paper, we reviewed all of the issues mentioned above in detail.
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    null    2008, 7 (2): 105-106.  
    Abstract456)   HTML0)    PDF(pc) (505KB)(1482)      
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    The clinical significance of transmembrane pressure monitoring in hemodialysis
    Chinese Journal of Blood Purification    2018, 17 (07): 490-493.   DOI: 10.3969/j.issn.1671-4091.2018.07.015
    Abstract626)      PDF(pc) (396KB)(1755)      
    【Abstract】This paper analyzes the causes of transmembrane pressure change and its unfavorable effects. We focuse on the principle of transmembrane pressure monitoring in dialysis machine. We particularly emphasize the training for medical staffs about the importance of transmembrane pressure monitoring and the manipulation of relevant preventive measures to achieve safe and efficient use of dialysis.
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    null    2006, 5 (11): 792-794.  
    Abstract423)   HTML1)    PDF(pc) (248KB)(2256)      
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    null    2007, 6 (8): 444-445.  
    Abstract365)   HTML1)    PDF(pc) (231KB)(1395)      
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    Chinese Journal of Blood Purification    2013, 12 (03): 156-158.  
    Abstract152)   HTML0)    PDF(pc) (167KB)(1293)      
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    Interpretation of the KDOQI Clinical Practice Guideline for Vascular Access, 2019 version
    Chinese Journal of Blood Purification    2020, 19 (07): 482-491.   DOI: 10.3969/j.issn.1671-4091.2020.07.013
    Abstract1437)      PDF(pc) (468KB)(2490)      
    【Abstract】In April 2020, the American National Kidney Foundation made a major update to the Kidney Disease Outcomes Quality Initiative (KDOQI) Clinical Practice Guideline for Vascular Access, and carried out various treatments for the survival plan of end-stage renal disease patients, including the life plan of end-stage renal disease patients, the selection of vascular access, and the new methods for handling specific complications. This article interprets this guideline according to the conditions of our country, helps doctors and patients make decisions on the treatment mode and vascular access for end-stage renal disease, and brings
    directional suggestions for subsequent research.
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    The developmental history of peritoneal dialysis in China in the 70 years
    Chinese Journal of Blood Purification    2019, 18 (10): 661-663.   DOI: 10.3969/j.issn.1671-4091.2019.10.001
    Abstract1023)      PDF(pc) (391KB)(2399)      
    【Abstract】There are about 1,000,000~2,000,000 patients with end-stage renal disease (ESRD) in China, which consumes huge medical resources and results in great economic burden to the society. Peritoneal dialysis (PD) has the advantages of convenience, safe, effective and home treatment, becoming one of the alternative treatment methods suitable for ESRD patients in China. The number of registered PD patients increases nearly 20 times from 4,380 in 1999 to 86,264 by the end of 2018. With the improvement of dialysis registration system, the widespread utilization of standard PD operating protocols, and the increase of high- quality clinical studies on PD in China, we have achieved continuous advances in PD quality, large experiences in treatment and management of PD, and excellent reputations about the treatment of PD in the international community.
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    Chinese Journal of Blood Purification    2015, 14 (06): 375-378.   DOI: 10.3969/j.issn.1671-4091.2015.06.014
    Abstract262)   HTML1)    PDF(pc) (572KB)(2636)      
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    Chinese Journal of Blood Purification    2021, 20 (11): 721-727.   DOI: 10.3969/j.issn.1671-4091.2021.11.001
    Abstract951)      PDF(pc) (395KB)(1284)    PDF(mobile) (395KB)(49)   
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    The erasons of A-V fictula plug and the care measures in maintain hemodialysis patients
    Chinese Journal of Blood Purification    2013, 12 (10): 576-578.  
    Abstract292)   HTML4)    PDF(pc) (293KB)(1336)      
    【Abstract】: Objective Purpose:Analysising the reasons of A-V fistula plug in maintain hemodialysis patients and then to improve the care measures. Methods: Retrospective analysis the hemodialysis records of 109 patients in our hospital from Jan. 2011 to Dec. 2011. Results:There were 10 patients occurring A-V fistula plug(9.17%).Bad vascular conditions were 2,excessive ultrafiltration were 4,repeated fixed-point puncture were 3,and oppression improper was 1 of them all. Conclusion:Inappropriate care may cause the A-V fistula plug.
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    The new classification of uremic toxins
    LI Chao, WEI Tao
    Chinese Journal of Blood Purification    2023, 22 (11): 801-805,815.   DOI: 10.3969/j.issn.1671-4091.2023.11.001
    Abstract362)      PDF(pc) (521KB)(697)      
    ?The retention and increase of uremic toxin will lead to a series of uremic symptoms, which will affect many systems of the whole body, and lead to the decline of patients' quality of life and high mortality. In 2003, the European Uremic Working Group classified uremic toxins into three groups according to their physical chemistry properties: water-soluble small molecule compounds, protein-binding compounds, and middle molecule compounds. With the new understanding of uremic solutes, the new data of sources and the development of hemodialysis methods and membrane materials, the previous classification can not fully adapt to the new progress in the field of blood purification. Accordingly, in november-december 2020, Claudio R, as president of the General Assembly, convened an expert meeting and prepared an expert consensus that provided new insights into the definition and classification of uremic toxin  tails the expert group's consensus recommendations for new definitions and more clinically oriented new classifications of uremic toxins.
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    null    2006, 5 (4): 205-207.  
    Abstract434)   HTML1)    PDF(pc) (261KB)(2428)      
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    Prevention and treatment of hypotension during hemodialysis
    CAI Li;ZUO Li
    null    2008, 7 (1): 3-5.  
    Abstract631)   HTML8)    PDF(pc) (467KB)(2786)      
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    null    2007, 6 (3): 145-149.  
    Abstract406)   HTML0)    PDF(pc) (314KB)(1107)      
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    Comparison of the advantages and disadvantages of several continuous renal replacement therapy technologies
    Chinese Journal of Blood Purification    2021, 20 (12): 801-804.   DOI: 10.3969/j.issn.1671-4091.2021.12.003
    Abstract676)      PDF(pc) (469KB)(1094)      
    【Abstract】Continuous renal replacement therapy (CRRT) has the roles of ultrafiltration to remove excess water, convection to clear medium and small molecular solutes, and adsorption to eliminate inflammatory mediators. The therapeutic models of CRRT are developed progressively, such as continuous venous-venous hemofiltration (CVVH), continuous venous- venous hemodiafiltration (CVVHDF), high- volume hemofiltration (HVHF), continuous plasma filtration adsorption (CPFA), and slow continuous ultrafiltration (SCUF). CVVH is the most commonly used model, usually as an adjuvant method for refractory heart failure, severe acute pancreatitis, rhabdomyolysis, and many others; CVVHDF has been widely used for the treatment of sepsis;
    HVHF is a treatment often for severe sepsis and septic shock; CPFA can be used in severe inflammatory response syndrome and sepsis; SCUF is often used in patients with refractory heart failure, edema, and overload of extracellular fluid volume. Every CRRT technology has its own characteristics, and the selection of therapeutic model and dosage must be individualized based on clinical situation of the patient.
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    Research and Application Progress of Long acting Erythropoietin
    LIU Ai-chun, WEI Tao
    Chinese Journal of Blood Purification    2023, 22 (03): 161-163.   DOI: 10.3969/j.issn.1671-4091.2023.03.001
    Abstract327)      PDF(pc) (342KB)(789)      
    China has a large number of patients with renal anemia and tumor anemia after radiotherapy and chemotherapy. Long acting erythropoietin (EPO) has the advantages of long half-life and high biological activity. It can reduce the frequency and dose of administration, improve patient compliance and improve the effect of anemia treatment. This paper summarizes the design scheme, advantages and application prospects of long-acting EPO in order to provide a theoretical basis for promoting the wide application of long-acting EPO in China.
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    Chinese Journal of Blood Purification    2018, 17 (11): 769-772.   DOI: 10.3969/j.issn.1671-4091.2018.11.012
    Abstract449)      PDF(pc) (281KB)(2459)      
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    The cause of death and its related information in hemodialysis patients in China - enlightenment from the DOPPS study
    Chinese Journal of Blood Purification    2022, 21 (02): 89-93.   DOI: 10.3969/j.issn.1671-4091.2022.02.005
    Abstract1355)      PDF(pc) (430KB)(1238)      
    【Abstract】Although hemodialysis (HD) can improve the life expectancy of end stage renal disease (ESRD) patients, the risk of death is still significantly higher in HD patients than in general population. The purpose of this study was to explore the cause of death and its related information in HD patients in the China Dialysis Outcomes and Practice Patterns Study (DOPPS). Methods DOPPS is an international, prospective and observational study. China participated in the DOPPS 5 study (2012~2015) and has completed the follow-up of the cohort. A total of 1,427 patients were enrolled in the China DOPPS 5 study. Their demographics,
    primary cause of ESKD, comorbidities, dialysis prescription, laboratory examination results, and date, cause and other related information of death were recruited. The primary cause, date and place of death were then defined. Results A total of 1,427 HD patients were enrolled in the China DOPPS 5 study, including 473 cases in Beijing, 454 cases in Guangzhou and 500 cases in Shanghai. The average age of the patients was 59.4+14.9 years old, 55% were males, and 25.1% had diabetes. The mean follow-up period was 1.9 years (1.1, 2.1 years). During the follow-up period, 205 patients died, with the overall mortality of 14.4% and the annual average mortality of 8.8%. In the death patients, the median age was 70 (59, 79) years old, 56.1% were males, and the median dialysis vintage was 2.5 (1.0~5.0) years. The number of death patients in Beijing, Guangzhou and Shanghai were 67, 67 and 71 cases respectively, with the annual average mortality of 7.9%,10.0% and 8.6% respectively. The top three causes of death in HD patients were cerebrovascular events (19.3%, including ischemic stroke), congestive heart failure (18.2%) and pulmonary infection (11.6%); 105 cases died of cardiovascular diseases, accounting for 51.2% of the death patients. There were gender differences in the ranking of the main causes of death. In the died patients, 70.8% died in hospital and 27.0% died at home; HD treatment continued before death in 79.8% patients, and discontinued before death in 20.2%; 62.9% cases received
    hospice care before death; the risk time of death in a day was within 10pm~6am. Conclusion In the China DOPPS 5 study, the average annual mortality was 8.8%. The main cause of death was cardiovascular events. Among the single cause of death, cerebrovascular events (including ischemic stroke), congestive heart failure and pulmonary infection were the most common causes of death, and the causes of death seemed to be gender different. The terminal stage was present in most death patients, and 1/4 of death happened at home. Without medical intervention, the risk time of death in a day was from late night to early morning.
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    Chinese Journal of Blood Purification    2017, 16 (09): 577-581.   DOI: 10.3969/j.issn.1671-4091.2017.09.001
    Abstract483)      PDF(pc) (303KB)(1434)      
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    Application of anti-Xa factor activity assay in low molecular weight heparin anticoagulation in hemodialysis patients 
    WANG Zhen-xing, XU Leng-nan, FU Pei-jie, DANG Xin, MAO Yong-hui
    Chinese Journal of Blood Purification    2022, 21 (05): 365-368.   DOI: 10.3969/j.issn.1671-4091.2022.05.014
    Abstract796)      PDF(pc) (398KB)(777)      
    Low molecular weight heparin (LMWH) is one of the commonly used anticoagulants. Its anticoagulation effect and bleeding risk are often monitored by the anti-Xa factor activity. Appropriate anti-Xa factor activity range is also recommended in clinical guidelines. As for hemodialysis patients using LMWH, there is no consensus about the target range of anti-Xa factor activity. This review mainly discusses the value of anti-Xa factor activity assay in LMWH anticoagulation for hemodialysis and the recent progresses in its specific monitoring strategies.
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    Recent progresses in the pathogenesis of pruritus in maintenance hemodialysis patients
    Chinese Journal of Blood Purification    2021, 20 (01): 43-46.   DOI: 10.3969/j.issn.1671-4091.2021.01.10
    Abstract520)      PDF(pc) (411KB)(1738)      
    【Abstract】skin pruritus is a common symptom in end-stage renal disease patients undergoing maintenance hemodialysis (MHD). Pruritus affects the quality of life, causes anxiety, depression, sleep disorders, and unfavorable prognosis of the patients. Although many kinds of treatment can be used clinically, the curative effect is limited. The pathogenesis of pruritus is complicated. This paper expounds the pathogenesis of skin pruritus in MHD patients from the perspectives of dry skin, immune inflammation hypothesis, histamine, bivalent ions, opioid hypothesis, parathyroid hormone, peripheral neuropathy, dialysis adequacy and mode, and glycosylation hypothesis.
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    Chinese Journal of Blood Purification    2016, 15 (05): 266-268.   DOI: 10.3969/j.issn.1671-4091.2016.05.004
    Abstract231)   HTML0)    PDF(pc) (664KB)(1238)      
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