中国血液净化 ›› 2019, Vol. 18 ›› Issue (03): 149-152.doi: 10.3969/j.issn.1671-4091.2019.03.002

• 专题与讲座 • 上一篇    下一篇

自动化腹膜透析治疗急重症肾衰竭患者

马莹1,王颖1,陈丽萌1   

  1. 1. 中国医学科学院 北京协和医学院 北京协和医院肾内科
  • 收稿日期:2018-10-19 修回日期:2018-12-16 出版日期:2019-03-12 发布日期:2019-03-05
  • 通讯作者: 陈丽萌 chenlpumch@163.com E-mail:chenlpumch@163.com
  • 基金资助:

    中国医学科学院医学与健康科技创新工程(2016-I2M-2-004);中国医学科学院协和学者特聘教授基金

Automatic peritoneal dialysis for the treatment of critical patients with acute renal failure

  • Received:2018-10-19 Revised:2018-12-16 Online:2019-03-12 Published:2019-03-05

摘要: 【摘要】自动化腹膜透析(automated peritoneal,APD)因其便利性、灵活性的优势,正成为越来越多终末期肾病(end stage renal disease,ESRD)患者的选择,尤其是青壮年、婴幼儿、老年及溶质清除不充分、反复腹膜炎的患者。在紧急透析方面,APD 有利于减少腹膜透析相关并发症且更节省人力。由于APD血流动力学影响小、不需要抗凝和体外循环、医疗风险和成本相对较低,国内外部分研究者成功将APD 用于合并ESRD 的多种临床危重症的治疗,如充血性心力衰竭、急性心脑血管病变、急性胰腺炎等。床旁穿刺置管技术的发展极大推动了APD 在急性肾损伤(acute kidney injury,AKI)治疗中的应用,但仍需高质量的临床研究观察比较APD 与血液透析治疗AKI 的有效性和安全性。同时,作为一种新兴腹膜透析模式,APD 在腹腔感染的诊治、水的清除及营养状况影响等方面还需要更深入的研究。

关键词: 自动化腹膜透析, 急危重症, 紧急透析, 终末期肾脏病, 急性肾损伤

Abstract: 【Abstract】Because of the advantages of convenience and flexibility, automated peritoneal dialysis (APD) is becoming the choice for many end- stage renal disease (ESRD) patients, especially for those of young adults, infants, elderly, and peritoneal dialysis patients with inadequate clearance of solutes and recurrent peritonitis. APD has the advantages of labor- saving and prevention of peritoneal dialysis associated complications, and can be used in urgent start dialysis. APD has less hemodynamic disturbance and does not need anticoagulant and extracorporeal circulation, with lower medical risks and expenses. Recently, APD has been successfully used in the treatment of many acute and severe diseases, such as congestive heart failure, acute cardio-cerebrovascular disease and acute pancreatitis. Percutaneous catheterization at bedside facilitates the application of APD in acute kidney injury patients, but the efficacy and safety need to be further studied by comprehensive comparisons of APD and hemodialysis. As a new dialysis modality, APD in peritonitis diagnosis and treatment, water clearance and nutritional influence remain unknown and more investigations are required.

Key words: Automated peritoneal dialysis, Intensive medicine, Urgent start dialysis, End-stage renal disease, Acute kidney injury