中国血液净化

中国血液净化 ›› 2019, Vol. 18 ›› Issue (04): 250-253.doi: 10.3969/j.issn.1671-4091.2019.04.010

• 综述 • 上一篇    下一篇

锌延缓腹膜透析患者腹膜纤维化进程及相关机制研究

李继翠1,李艳琼1,卢雪红1   

  1. 1. 吉林大学第二医院肾病内科
  • 收稿日期:2018-10-22 修回日期:2018-11-04 出版日期:2019-04-12 发布日期:2019-04-12
  • 通讯作者: 卢雪红 changchunlxh@foxmail.com E-mail:changchunlxh@foxmail.corn

Zinc delays peritoneal fibrosis in peritoneal dialysis patients and its mechanism

  • Received:2018-10-22 Revised:2018-11-04 Online:2019-04-12 Published:2019-04-12

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摘要： 【摘要】腹膜透析(peritoneal dialysis，PD)是治疗终末期肾病(End-stage renal disease，ESRD)的一个行之有效的替代治疗措施，甚至成为肾脏替代治疗的首选方案。然而，随着腹膜透析(peritoneal dialysis，PD)治疗时间的延长，在非生物相容性腹膜透析液、腹膜炎、细胞因子、氧化应激等多方面因素的影响下，导致腹膜纤维化(peritoneal fibrosis,PF)，PD 患者腹膜超滤能力将逐渐下降，最终会出现超滤衰竭(ultrafiltration failure，UFF)，而腹膜纤维化是导致腹膜超滤衰竭的主要原因，是患者退出腹膜透析的主要原因。稳定的慢性PD 患者的队列中，体内锌的缺乏率较高。锌是一种重要的微量元素,在人体发挥重要作用，同时，锌也是一种抗氧化剂，具有改善微炎症状态、抗氧化应激反应及抗凋亡等作用，可以延缓腹膜纤维化的进程。本文将对国内外学者近年来对腹膜纤维化的防治所做的探索进行总结与归纳，同时也对锌防治腹膜纤维化的可能的机制进行分析。

关键词: 锌, 炎症反应, 氧化应激反应, 细胞因子, 细胞凋亡, 腹膜纤维化

Abstract: 【Abstract】Peritoneal dialysis (PD) is an alternative treatment effective for end-stage renal disease (ESRD) patients and even the first choice of renal replacement therapy. With the longer duration of PD, however, nonbiocompatible dialysate, peritonitis, cytokines, oxidative stress and other factors cause peritoneal fibrosis (PF), leading to the gradual decrease of peritoneal ultrafiltration capacity and eventually to ultrafiltration failure. PF is the main etiology for patients to give up PD. In the cohort of patients with chronic stable PD, the prevalence of zinc deficiency is high. Zinc is an important trace element that plays an important role in the body. Zinc as an antioxidant alleviates micro-inflammation, oxidative stress and cell apoptosis, as well as the progression of PF. This article summarizes the recent advances made by foreign and Chinese researchers in the prevention and treatment of PF, and explores the possible mechanisms underlying the prevention and treatment of PF by zinc.

Key words: Zinc, Inflammation, Oxidative stress, Cytokines, Cell apoptosis, Peritoneal fibrosis