关键词: 腹膜透析, 凝血, 糖尿病, 脂代谢异常, 微炎症

Abstract: 【Abstract】Objective To investigate the status of coagulation function status and its influencing factors in peritoneal dialysis (PD) patients. Methods Patients who received peritoneal dialysis for more than 3 months in the Department of Nephrology, Renmin Hospital of Wuhan University from January 2017 to October 2019 were included, and their clinical data were retrospectively analyzed. According to the value of fibrinogen (FIB), patients were divided into group H (FIB＞4g/L, n=64) and group N (FIB ≤ 4g/L, n=108). The clinical data of the two groups were compared. Spearman correlation analysis was used to explore the relationship between clinical data and FIB, and logistic regression was used to analyze the risk factors of FIB elevation. Results 172 PD patients were included. FIB increased in 37.21% patients. Logistic regression analysis showed that total cholesterol (OR=2.394, 95% CI 1.410～4.064, P=0.001), high- density lipoprotein (OR= 23.731, 95% CI 2.518～242.900, P=0.006), lipoprotein-a (OR= 1.002, 95% CI 1.000～1.004, P=0.010), highsensitive C-reactive protein (OR=1.548,95% CI 1.307～1.83, P=0.000) and diabetes mellitus (OR=8.614, 95% CI 1.657～44.792, P=0.010) were risk factors for high FIB. Conclusion PD patients are in a hypercoagulable state, and coagulation function is related to diabetes mellitus, lipid metabolism and micro-inflammation. The regulation of lipid metabolism and the control of micro-inflammation may be helpful to the treatment of coagulation disorder in PD patients.

Key words: Peritoneal dialysis, Coagulation, Diabetes mellitus, Dyslipidemia, Micro-inflammation