B 型利钠肽/N 末端B 型利钠肽原在慢性肾脏病中的研究进展

doi:10.3969/j.issn.1671-4091.2021.07.002

摘要/Abstract

摘要： 【摘要】心血管疾病(cardiovascular disease,CVD)是慢性肾脏病(chronic kidney disease,CKD)患者常见的并发症，也是终末期肾病患者的主要死亡原因。故在CKD 患者中早期识别并干预CVD 是至关重要的。B 型利钠肽(BNP)和N 末端B 型利钠肽原(NT-proBNP)作为心脏生物标志物，已被用来诊断心力衰竭和评估病情严重程度与预后。但对于CKD患者来说，CKD本身与透析治疗等因素往往会影响BNP、NTproBNP水平，使其在CKD 患者中诊断心力衰竭和评估病情严重程度与预后方面面临挑战。本综述通过对BNP 和NTproBNP 概况回顾，分析了CKD 患者血清BNP 和NT-proBNP 的水平及影响因素，并对BNP 和NTproBNP在CKD中的应用前景作一综述。

关键词: 慢性肾脏病, 心血管疾病, B 型利钠肽, N末端B 型利钠肽原

Abstract: 【Abstract】Cardiovascular disease (CVD) is a common complication in chronic kidney disease (CKD) patients and the main cause of death in patients with end-stage renal disease. Early identification and intervention of CVD is therefore essential to CKD patients. The two cardiac biomarkers, B-type natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP), have been used to diagnose heart failure and to assess the severity and prognosis of CVD. However, CKD itself and dialysis treatment often affect serum levels of BNP/NT-proBNP and thus the usefulness of BNP/NT-proBNP in the diagnosis of heart failure and the assessment of severity and prognosis of CVD in CKD patients. This review analyzes the serum levels of BNP/NT-proBNP and their influencing factors in CKD patients through a survey of BNP/NT-proBNP, and briefly discusses the application prospects of BNP/NT-proBNP in CKD patients with CVD.

Key words: Chronic kidney disease, Cardiovascular disease, B-type natriuretic peptide, N-terminal pro-B-type natriuretic peptide

中图分类号:

R692

赵东方, 戎殳. B 型利钠肽/N 末端B 型利钠肽原在慢性肾脏病中的研究进展[J]. 中国血液净化, 2021, 20(07): 437-440.

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