中国血液净化

中国血液净化 ›› 2021, Vol. 20 ›› Issue (08): 536-539.doi: 10.3969/j.issn.1671-4091.2021.08.008

• 临床研究 • 上一篇    下一篇

维持性血液透析相关肌肉减少症的患病率及危险因素的横断面调查

罗楠1,李新伦2,陈凤锟3,玄方4,赵长征5,刘静民6,伦立德2   

  1. 1河北北方学院研究生院
    2空军特色医学中心肾病科
    3解放军总医院第四医学中心肾内科
    4解放军总医院第六医学中心肾内科
    5北京仁圣医院血液净化中心
    6清华大学体育部

  • 收稿日期:2021-04-29 修回日期:2021-06-01 出版日期:2021-08-21 发布日期:2021-08-05
  • 通讯作者: 伦立德 lunlideldm@163.com E-mail:1079087896@qq.com

A cross-sectional study on the prevalence and risk factors of maintenance hemodialysis-associated sarcopenia

  1. 1Graduate School of Hebei North University, Zhangjiakou 075000, China;  2Department of Nephrology, Air Force Medical Center of PLA, Beijing 100142, China;  3Department of Nephrology, the Fourth Medical Center of Chinese PLA General Hospital, Beijing 100048, China;  4Department of Nephrology, the Sixth Medical Center of Chinese PLA General Hospital, Beijing 100142, China;  5Blood Purification Center, Beijing Rensheng Hospital,Beijing 102300,China;  6Athletic Department, Tsinghua University, Beijing 100084, China
  • Received:2021-04-29 Revised:2021-06-01 Online:2021-08-21 Published:2021-08-05

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摘要： 【摘要】目的研究维持性血液透析(maintenance hemodialysis，MHD)相关肌肉减少症(sarcopenia，简称肌少症)的患病率及危险因素。方法入选359 例MHD 患者，收集患者相关资料测量肌肉质量、力量及肌肉功能，将研究对象分成肌少症组和非肌少症组，分析肌少症的患病率及危险因素。结果本研究纳入359 名MHD 患者，肌少症83 例，非肌少症276 例，肌少症患病率为23.1%。多因素Logistic 回归分析显示年龄(OR=1.962,95%CI：1.264～3.044,P =0.003)、营养不良(OR=2.697,95% CI：1.283～5.669, P=0.009)及抑郁(OR=1.707,95% CI：1.116～2.611,P =0.014)是肌少症的独立危险因素，体质量指数 (BMI)是肌少症的保护因素(OR=0.040, 95% CI：0.015～0.108,P＜0.001)。结论MHD 肌少症患病率高达23.1%，年龄、营养不良、抑郁是其独立危险因素，BMI是其保护性因素。

关键词: 维持性血液透析, 肌肉减少症, 患病率, 危险因素

Abstract: 【Abstract】Objective To study the prevalence and risk factors of maintenance hemodialysis (MHD)-associated sarcopenia. Methods A total of 359 MHD patients were enrolled in this study. Clinical data of the patients were collected. Muscle mass, strength and muscle function were tested. Subjects were divided into sarcopenia group and non-sarcopenia group, and the prevalence and risk factors of sarcopenia were then analyzed. Results The 359 MHD patients were divided into the sarcopenia group (n=83) and the non-sarcopenia group (n=276). The prevalence of MHD-associated sarcopenia in the patients was 23.1%. Multivariate logistic regression analysis showed that age (OR=1.962, 95% CI=1.264~3.044, P=0.003), malnutrition (OR=2.697,
95% CI=1.283~5.669, P=0.009) and depression (OR=1.707, 95% CI=1.116~2.611, P=0.014) were the independent risk factors for sarcopenia, and BMI (OR=0.040, 95% CI=0.015~0.108, P＜0.001) was a protective factor for sarcopenia. Conclusion The prevalence of MHD-associated sarcopenia was 23.1%. Age, malnutrition and depression were the independent risk factors for sarcopenia, and BMI was a protective factor for sarcopenia.

Key words: Maintenance hemodialysis, Sarcopenia, Prevalence, Risk factor

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