中国血液净化

中国血液净化 ›› 2022, Vol. 21 ›› Issue (06): 398-402.doi: 10.3969/j.issn.1671-4091.2022.06.004

• 临床研究 • 上一篇    下一篇

河北省血液透析患者恶性肿瘤发生情况的流行病学研究

周 薇   史宁宁   靳晶晶   程美娟   徐金升   

  1. 河北医科大学第四医院肾内科
  • 收稿日期:2022-01-24 修回日期:2022-03-10 出版日期:2022-06-12 发布日期:2022-06-12
  • 通讯作者: 徐金升 xjs5766@126.com E-mail:xjs5766@126.com
  • 基金资助:
    河北省医学技术跟踪项目(G2018050)；河北省重点研发计划项目(20377704D)；河北省科技计划项目(16397733D)

Epidemiological study on the incidence of malignant tumors in maintenance hemodialysis patients in Hebei Province

  • Received:2022-01-24 Revised:2022-03-10 Online:2022-06-12 Published:2022-06-12
  • Contact: XU Jin-sheng xjs5766@126.com E-mail:xjs5766@126.com

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摘要： 讨河北省维持性血液透析(maintenance hemodialysis，MHD)患者恶性肿瘤的发生情况。 方法　根据纳排标准，截至2019年12月31日，从全国血液净化病例信息登记系统中纳入20 035例研究对象，记录首次透析时间，对其恶性肿瘤的发生情况进行描述性研究。 结果　河北省一般人群恶性肿瘤标化发病率为247.9/10万人年。本研究共纳入20 035例MHD患者，其中新发恶性肿瘤113例，恶性肿瘤标化发病率278.8/10万人年。泌尿生殖系统的发病风险是一般人群的1.7倍(Z =3.540,       P =0.0004)。非糖尿病患者恶性肿瘤标准累积发病率高于糖尿病患者(0.22%比0.16%，χ²=340.245，P＜0.001)，女性高于男性(0.22%比0.17%，χ²=215.845，P＜0.001)。结论　河北省MHD患者新发恶性肿瘤发病率明显高于一般人群，泌尿生殖系统恶性肿瘤的发病风险最高，临床上应加强对该系统恶性肿瘤的早期筛查，提高MHD患者生存质量及预后。

关键词: 维持性血液透析, 恶性肿瘤, 发病率

Abstract: Objective To investigate the incidence of malignant tumors in maintenance hemodialysis (MHD) patients in Hebei province.  Methods  A total of 20,035 subjects were extracted from the National Blood Purification Case Information Registration System before the date of December 31, 2019 according to the inclusion and exclusion criteria of this study. The time of first dialysis was recorded, and the occurrence of malignant tumors in these patients was described.  Results  The standardized morbidity rate of malignant tumors was 247.9/100,000/year in the general population in Hebei Province. In the 20,035 MHD patients, a total of 113 patients were found to have newly diagnosed malignant tumors, with a standardized incidence of malignant tumors of 278.8/100,000/year; the risk of genitourinary malignancies was 1.7 times higher than that in the general population (Z=3.540, P=0.004); the standard cumulative incidence of malignancy was higher in non-diabetic patients than in diabetic patients (0.22% vs. 0.16%, χ²=340.245, P＜0.001), and was higher in women than in men (0.22% vs. 0.17%, χ²=215.845, P＜0.001).  Conclusion  The incidence of malignant tumor in the MHD patients was obviously higher than that in the general population in Hebei Province, especially the incidence of genitourinary malignancies. Therefore, monitoring of genitourinary malignancies is required to improve the quality of life and prognosis of MHD patients.

Key words: Maintenance hemodialysis, Malignant tumor, Incidence

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