中国血液净化

中国血液净化 ›› 2022, Vol. 21 ›› Issue (07): 541-544.doi: 10.3969/j.issn.1671-4091.2022.07.017

• 护理研究 • 上一篇    

TR-350免疫吸附应用于视神经脊髓炎谱系疾病中临床疗效及护理

熊云锦    周 冉    谷 静    龚 勇   张 寅    周亦伦   

  1. 100070 北京，1首都医科大学附属北京天坛医院肾内科
    100068 北京，    2中国康复研究中心肾内科
  • 收稿日期:2021-10-08 修回日期:2021-12-08 出版日期:2022-07-12 发布日期:2022-07-12
  • 通讯作者: 熊云锦 E-mail:xiongyj02@sina.com

TR-350 immunoadsorption used in the neuromyelitis optica spectrum disorders: its clinical effects and#br# nursing methods

  1. Department of Nephrology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China ； 2Department of Nephrology, China Rehabilitation Research Center, Beijing 100068, China
  • Received:2021-10-08 Revised:2021-12-08 Online:2022-07-12 Published:2022-07-12

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摘要： 目的 总结TR-350免疫吸附治疗国家罕见病——视神经脊髓炎谱系疾病的临床疗效和护理
方法。 方法 收集患者一般情况、治疗过程中的异常反应、设备报警、相关处理及临床结果。 结果 免疫
吸附治疗后患者视力及神经功能均较治疗前有明显改善，扩展残疾状态量表评分(extended disability status scale,EDSS)显著下降(t=5.404，P =0.005)。水通道蛋白4的免疫球蛋白血清自身抗体水平
显著下降(t=10.793，P＜0.001)。68例次治疗中出现低血压1例次，卡他症状5例次，设备报警14例次。
仅有1例次非计划结束治疗。 结论 免疫吸附效果明显但操作复杂，护士需要严格遵守操作流程，同时
具备分析设备报警原因和处理突发事件的能力，以保证治疗顺利进行。

关键词: 免疫吸附, 视神经脊髓炎谱系疾病, 护理

Abstract: Objective To summarize the clinical effects and nursing methods of TR-350 immunoadsorption in treatment of the national rare disease, the neuromyelitis optica spectrum disorders. Methods General
situation of the patients, abnormal reactions during treatment, equipment alarm, management and clinical results were collected. Results Visual acuity and nerve function improved significantly after the immunoadsorption treatment. The extended disability status scale (EDSS) reduced from (5.84 ± 2.16) to (4.46 ± 2.13)
(t=5.404, P=0.005). The concentration of anti- aquaporin- 4 autoantibody also decreased significantly from
(72.14±24.21)μ/ml to (16.72±6.63)μ/ml (t =10.793, P＜0.001). In the 68 cases during treatment, hypotension
occurred in one case, catarrh symptoms in 5 cases, equipment alarm in 14 cases, and unplanned termination of
the treatment in one case. Conclusions The immunoadsorption effect is obvious but the operation is complicated. Therefore, the operation nurses are required to strictly follow the operation processes, and have the abilities to analyze the cause of equipment alarm and to manage the emergencies to ensure success of the treatment.

Key words: Department of Nephrology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China , 2Department of Nephrology, China Rehabilitation Research Center, Beijing 100068, China

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