中国血液净化

中国血液净化 ›› 2022, Vol. 21 ›› Issue (10): 754-757.doi: 10.3969/j.issn.1671-4091.2022.10.011

• 综述 • 上一篇    下一篇

硫酸吲哚酚与慢性肾脏病及其并发症的研究进展

杨靖宇   方敬爱   张晓东    刘文媛    张紫媛    胡雅玲   

  1. 030001 太原，1山西医科大学第一临床医学院
    030001 太原，2山西医科大学第一医院肾内科
  • 收稿日期:2022-04-07 修回日期:2022-06-29 出版日期:2022-10-12 发布日期:2022-10-12
  • 通讯作者: 方敬爱 E-mail:fja3455001@126.com
  • 基金资助:
    国家自然科学青年基金(81803947)；山西省面上青年基金(201901D211484)

Research progress in the effects of indoxyl sulfate on chronic kidney disease and its complications   

YANG Jing-yu,  FANG Jing-ai,  ZHANG Xiao-dong,  LIU Wen-yuan,  ZHANG Zi-yuan,  HU Ya-ling   

  1. The First Clinical Medical College of Shanxi Medical University, Taiyuan 030001, China; 2Department of Nephrology, Shanxi Medical University First Hospital, Taiyuan 030001, China
  • Received:2022-04-07 Revised:2022-06-29 Online:2022-10-12 Published:2022-10-12
  • Contact: 030001 太原，2山西医科大学第一医院肾内科 E-mail:fja3455001@126.com

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摘要： 硫酸吲哚酚(indoxyl sulfate,IS)是一种肠源性尿毒症毒素，近些年的研究表明IS在体内积聚不仅会导致慢性肾脏病(chronic kidney disease,CKD)进展，还参与CKD患者心血管疾病、肌肉减少症、认知功能障碍、骨病及贫血等多种并发症的进展，从而降低患者的生活质量及生存率，故本文将围绕近年来IS与CKD及其并发症的相关研究来展开综述，旨在为CKD的防治提供新思路。

关键词: 硫酸吲哚酚, 慢性肾脏病, 临床结局, 血液净化

Abstract: Indoxyl sulfate (IS) is a uremic toxin of intestinal origin. Recent studies have shown that the accumulation of IS in the body will not only lead to the progression of chronic kidney disease (CKD), but also participate in the progression of cardiovascular disease, sarcopenia, cognitive impairment, osteopathy and anemia in CKD patients, thus reducing the quality of life and survival rate of CKD patients. This paper reviews the studies relating to the effects of IS on CKD and its complications in recent years, in order to provide new ideas for the prevention and intervention of CKD.

Key words: ndoxyl sulfate, Chronic kidney disease, Clinical outcome, Blood purification

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