中国血液净化

中国血液净化 ›› 2024, Vol. 23 ›› Issue (02): 130-133.doi: 10.3969/j.issn.1671-4091.2024.02.011

• 综述 • 上一篇    下一篇

低氧诱导因子与肾纤维化关系的研究进展

闫 桐    贾新燕    郭明好   

  1. 453100 卫辉,1新乡医学院第一附属医院肾内科
  • 收稿日期:2023-10-23 修回日期:2023-11-28 出版日期:2024-02-12 发布日期:2024-02-12
  • 通讯作者: 郭明好 E-mail:13937315636@163.com
  • 基金资助:
    2020年度河南省医学科技攻关计划联合共建项目(LHGJ20200494)

Research advances in the relationship between hypoxia-inducible factor-1α and renal fibrosis

YAN Tong, JIA Xin-yan, GUO Ming-hao   

  1. Department of Nephrology, The First Affiliated Hospital of Xinxiang Medical College, Weihui 453100, China
  • Received:2023-10-23 Revised:2023-11-28 Online:2024-02-12 Published:2024-02-12
  • Contact: 453100 卫辉,1新乡医学院第一附属医院肾内科 E-mail:13937315636@163.com

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摘要： 肾纤维化是各种肾脏疾病的共同病理特征,以进行性细胞外基质(extracellular matrix,ECM)堆积为特点。低氧诱导因子(hypoxia-inducible factor,HIF)是机体对缺氧反应的关键调节因子,通过调节ECM的合成。上皮-间充质转化(epithelial-mesenchymal transition,EMT)及多种信号转导通路发挥促纤维化作用。本文拟就HIF在肾纤维化中的研究进展进行综述。

关键词: 缺氧, 低氧诱导因子, 肾纤维化, 上皮-间充质转化

Abstract: Renal fibrosis is the common pathological hallmark of various chronic kidney diseases, characterized by progressive accumulation of extracellular matrix (ECM). Hypoxia-inducible factor (HIF) is a key regulator of body’s response to hypoxia. HIF regulates ECM synthesis, epithelial-mesenchymal transition (EMT) and pro-fibrosis signaling pathways. This review summarized the relationship between HIF-1α and renal fibrosis.

Key words: Hypoxia, Hypoxia-inducible factor, Renal fibrosis, Epithelial-mesenchymal transition

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