中国血液净化

中国血液净化 ›› 2022, Vol. 21 ›› Issue (02): 81-84.doi: 10.3969/j.issn.1671-4091.2022.02.003

• 专题与讲座 • 上一篇    下一篇

高截留滤器-连续性肾脏替代治疗在脓毒血症合并急性肾损伤中的应用进展

宋小炜1,张凌2   

  1. 1西部战区空军医院/中国人民解放军第四五二医院肾内科
    2四川大学华西医院肾脏内科

  • 收稿日期:2021-08-19 修回日期:2021-11-20 出版日期:2022-02-12 发布日期:2022-02-17
  • 通讯作者: 张凌 zhanglinglzy@163.com E-mail:andrewsss@foxmail.com
  • 基金资助:
    四川省科技计划项目(2020YFG0105)；四川大学华西医院临床研究孵化项目(2018HXFX018)

Application of high cut-off membranes with continuous renal replacement therapy in septic acute kidney injury

  1. 1Department of Nephrology, The air force hospital of Chinese People's Liberation Army (PLA) Western Theater Command, Chengdu 610061, China;  2Department of Nephrology, West China clinical medical college of sichuan University, Chengdu 610044, China
  • Received:2021-08-19 Revised:2021-11-20 Online:2022-02-12 Published:2022-02-17

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摘要： 【摘要】随着连续性肾脏替代治疗(continuous renal replacement therapy,CRRT)技术和透析膜技术的进步并行，针对脓毒血症合并急性肾损伤的治疗手段逐渐丰富，其中高截留滤器在清除传统滤器不能有效覆盖的炎症因子上更有前景的获益，其在临床实践中有望更有选择性的去除大分子量的炎症介质，从而在抗感染治疗以外通过血液净化的方式进行全身炎症状态的有效干预。本综述特别关注高截留滤器的临床应用，包括已发表的该滤器相关研究中对炎症因子清除和对预后改善情况，概括了目前该滤器已发表研究的差异性和潜在应用方向。

关键词: 脓毒血症合并急性肾功能不全, 高截留滤器, 连续性肾脏替代治疗, 炎症因子

Abstract: 【Abstract】With the Innovation of continuous renal replacement therapies (CRRT) technology and dialysis membrane, the treatment methods for sepsis complicated with acute kidney injury have been gradually diversified in recent years. Among those innovation, High cut-off (HCO) membrane have more promising benefits in the removal of inflammatory factors which could not be effectively removed by the traditional high-flux filters. HCO membrane is expected to be more selective in the clinical practice to remove large molecular weight inflammatory mediators, thus providing effective intervention for systemic inflammation status by
blood purification in addition to anti-infection therapy. Our review focuses specifically on the clinical application of HCO therapy, including published studies focused on the removal of inflammatory cytokines by HCO membrane and its improvement in prognosis. We also summarize the differences of those published studies and potential applications of HCO membrane.

Key words: Septic acute kidney injury, High cut-off membranes, Continuous renal replacement therapy, Cytokine

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