中国血液净化

中国血液净化 ›› 2022, Vol. 21 ›› Issue (02): 94-97.doi: 10.3969/j.issn.1671-4091.2022.02.006

• 临床研究 • 上一篇    下一篇

血小板/淋巴细胞比值与维持性血液透析患者全因死亡的相关性

杨原1,2,陈华茜2   

  1. 1锦州医科大学国药东风总医院研究生培养基地
    2湖北医药学院附属国药东风总医院肾内科

  • 收稿日期:2021-06-28 修回日期:2021-11-13 出版日期:2022-02-12 发布日期:2022-02-17
  • 通讯作者: 陈华茜 chen.hua.qian@hotmail.com E-mail:chenhuaqian@163.com

The correlation between platelet/lymphocyte ratio and all-cause death in patients with maintenance hemodialysis

  1.  1Graduate Training Base, Dongfeng General Hospital of Traditional Chinese Medicine, Jinzhou Medical University, Shiyan 442000, China;  2Department of Nephrology, Dongfeng General Hospital of Traditional Chinese Medicine Affiliated to Hubei University of Medicine, Shiyan 442000, China
  • Received:2021-06-28 Revised:2021-11-13 Online:2022-02-12 Published:2022-02-17
  • Contact: CHEN Huaqian E-mail:chenhuaqian@163.com

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摘要： 【摘要】目的探讨血液透析患者血小板/淋巴细胞比值(platelet/lymphocyte ratio, PLR)对维持性血液透析(maintenance hemodialysis, MHD)患者全因死亡率的影响。方法回顾性收集在锦州医科大学国药东风总医院血液透析中心规律透析3个月以上、病情平稳的MHD 患者的临床资料。根据血常规计算PLR，按其四分位数将患者分为4组(Q1～Q4 组)。采用Kaplan-Meier及Log-rank检验比较4 组患者生存率。采用COX回归模型分析MHD患者全因死亡的危险因素。结果共283例MHD患者被纳入研究，平均年龄(63.88±15.40)岁，中位透析龄3.24(1.82, 6.05)年。Kaplan-Meier生存曲线显示，基线PLR≥196.44 的患者全因死亡率较高(Log-rank 检验χ2=53.128, P＜0.001)。校正多项混杂干扰因素后，PLR仍与全因死亡风险相关，其中Q4 组患者全因死亡发生风险高出Q1 组3.776 倍(HR=4.776，95% CI1.580～14.437，P=0.006)。结论高PLR 与MHD 患者高全因死亡率有关，是MHD 患者全因死亡的强预测因子。

关键词: 血小板/淋巴细胞比值, 肾透析, 死亡率, 危险因素

Abstract: 【Abstract】Objective To explore the effect of platelet/lymphocyte ratio (PLR) on all-cause mortality in maintenance hemodialysis (MHD) patients. Methods The MHD patients with regular hemodialysis for more than 3 months and stable condition and treated in the Hemodialysis Center, Dongfeng General Hospital of Traditional Chinese Medicine, Jinzhou Medical University were retrospectively analyzed. PLR was calculated from the results of blood routine. The patients were divided into four groups (Q1~Q4 group) based on quartile range. Kaplan-Meier method and log-rank test were used to compare the survival rates among the 4 groups. COX regression model was used to analyze the risk factors for all-cause death in MHD patients. Results A total of 283 MHD patients were enrolled in this study, with the average age of 63.88±15.40 years old, and the median dialysis vintage of 3.24 (1.82, 6.05) months. Kaplan-Meier survival curve showed that patients with baseline PLR ≥196.44 had higher all-cause mortality (log-rank test, χ2=53.128, P＜0.001). After adjustment for multiple confounding factors, PLR was still linked to the risk of all- cause death. The risk of all- cause death in the Q4 group was 3.776 times higher than that in the Q1 group (HR=4.776, 95% CI 1.580～14.437, P=0.006). Conclusion Higher PLR is associated with higher all-cause mortality in MHD patients and is a strong predictor for all-cause mortality in MHD patients.

Key words: Platelet/lymphocyte ratio, Renal dialysis, Mortality, Risk factors

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