中国血液净化

中国血液净化 ›› 2022, Vol. 21 ›› Issue (03): 172-176.doi: 10.3969/j.issn.1671-4091.2022.03.007

• 临床研究 • 上一篇    下一篇

相角与维持性血液透析患者肌少症的关系及其预测价值分析

丁妍1,常立阳1,张红梅1   

  1. 1浙江中医药大学附属杭州市中医院血液净化中心
  • 收稿日期:2021-08-26 修回日期:2022-01-13 出版日期:2022-03-12 发布日期:2022-03-16
  • 通讯作者: 常立阳 changliyang@163.com E-mail:915709504@qq.com
  • 基金资助:
    浙江省医药卫生科技计划项目(2019KY138)

The correlation of phase angle with sarcopenia and its diagnostic value in maintenance hemodialysis patients

  1. 1Department of Blood Purification Centre, Hangzhou Traditional Chinese Medicine Hospital Affiliated to Zhejiang Traditional Chinese Medicine University, Hangzhou 310007, China
  • Received:2021-08-26 Revised:2022-01-13 Online:2022-03-12 Published:2022-03-16

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摘要： 【摘要】目的分析生物电阻抗法测量的相角与维持性血液透析(maintenance hemodialysis，MHD)患者肌少症的关系，并探索相角在肌少症中的作用。方法选取在浙江中医药大学附属杭州市中医院规律透析且病情稳定的MHD 患者346 例，收集相关资料，采用多元线性回归分析筛选MHD 患者相角的影响因素，并进一步采用受试者工作特征曲线图和曲线下面积评价相角对肌少症的预测价值。结果多元线性回归分析显示相角与年龄、白蛋白、瘦体质量、骨骼肌质量指数、握力、步速呈线性关系(B=-0.192、0.180、0.889、0.978、0.212、0.210，均P＜0.001)。相角检测肌少症的最佳临界值是4.67° ，曲线下面积为0.823，敏感性和特异性分别为86.7%和67.4%(P＜0.001)。结论本研究发现相角与MHD 患者的肌少症组分密切相关，是肌少症的重要预测因素，相角作为简便的临床指标可为MHD 人群肌少症的早期诊断提供客观参考依据。

关键词: 维持性血液透析, 肌少症, 相角, 人体成分

Abstract: 【Abstract】Objective This study aimed to analyze the correlation between phase angle measured by bioelectrical impedance method and sarcopenia in maintenance hemodialysis (MHD) patients and to explore the role of phase angle in sarcopenia. Methods We enrolled 346 MHD patients with regular dialysis in this study. Their relevant data were collected. Multivariate linear regression was used to analyze the influencing factors for phase angle in MHD patients. Receiver operating characteristic curve and area under the curve (AUC) were used to evaluate the predictive value of phase angle for sarcopenia. Results Multivariate linear regression showed that the phase angle was linear with age, albumin, fat free mass, skeletal muscle mass index, handgrip strength, gait speed (B=- 0.192, 0.180, 0.889, 0.978, 0.212 and 0.210 respectively; P＜0.05). The best cutoff value of phase angle for sarcopenia was 4.67° , with the AUC of 0.823, the sensitivity of 86.7%, and the specificity of 67.4% (P＜0.001). Conclusions This study found that phase angle was closely related to sarcopenia component in MHD patients, and was an important predictor for sarcopenia. As a simple and convenient clinical index, phase angle can provide objective reference for early diagnosis of sarcopenia in MHD patients.

Key words: Maintenance hemodialysis, Sarcopenia, Phase angle, Body composition

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