中国血液净化

中国血液净化 ›› 2023, Vol. 22 ›› Issue (07): 498-502.doi: 10.3969/j.issn.1671-4091.2023.07.005

• 临床研究 • 上一篇    下一篇

有氧联合阻抗运动对血液透析患者透析充分性和生活质量的影响

其其格    赵建荣   

  1. 010050 呼和浩特，1内蒙古医科大学附属医院肾内科
  • 收稿日期:2023-01-25 修回日期:2023-04-27 出版日期:2023-07-12 发布日期:2023-07-12
  • 通讯作者: 赵建荣 E-mail:jrzhao33@souhu.com

The effects of combined aerobic-resistance training on dialysis adequacy and quality of life in maintenance hemodialysis patients

QI Qi-ge1, ZHAO Jian-rong   

  1. Department of Nephrology, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China
  • Received:2023-01-25 Revised:2023-04-27 Online:2023-07-12 Published:2023-07-12
  • Contact: 010050 呼和浩特，1内蒙古医科大学附属医院肾内科 E-mail:jrzhao33@souhu.com

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摘要： 目的 探讨有氧联合阻抗运动对维持性血液透析(maintenance hemodialysis,MHD)患者透析充分性和生活质量的影响。 方法 选取2021年6月～2022年6月在内蒙古医科大学附属医院血液净化中心的MHD患者40例为研究对象，透析龄≥3个月，采用随机数字表法分为试验组(n=20)和对照组  (n=20)，透析期间对照组给予常规治疗，包括饮食指导、药物治疗和血液透析治疗。试验组在常规治疗基础上实行运动干预：进行为期24周的有氧联合阻抗运动，3次/w，每次45min。收集干预前后的血尿素氮，计算尿素清除指数(Kt/V)和尿素下降率(urea reduction rate,URR)，评估透析充分性。比较干预前后2组健康调查量表(short form 36 questionnaire,SF-36)变化，评价生活质量。 结果 运动干预24w后试验组Kt/V、URR、一般健康状况(general health status,GH)、躯体功能(physical function,PF)、活力(vitality,VT)、精神健康(mental health,MH)及SF-36总分明显高于对照组(t值分别为2.435、2.218、2.675、2.798、3.188、2.197、4.251，P值分别为0.020、0.033、0.011、0.008、0.003、0.034、＜0.001)；与基线水平相比，试验组24周时Kt/V、URR、一般健康状况(GH)、躯体功能(PF)、活力(VT)及SF-36总分明显升高(t值分别为-2.880、-7.543、-6.168、-3.587、-7.009、-7.521，P值分别为0.010、＜0.001、＜0.001、0.002、＜0.001、＜0.001)。 结论 有氧联合阻抗运动可以提高MHD患者透析充分性，改善患者生活质量。

关键词: 维持性血液透析, 有氧联合阻抗运动, 透析充分性, 生活质量

Abstract: Objective To explore the effect of combined aerobic-resistance training on dialysis adequacy and quality of life in maintenance hemodialysis (MHD) patients.  Methods  A total of 40 MHD patients treated in Blood Purification Center of the Affiliated Hospital of Inner Mongolia Medical University from June 2021 to June 2022 were recruited as the study subjects. Their hemodialysis age was≥3 months. They were divided into the test group (n=20) and the control group (n=20) by random number table method. Patients in the control group were given routine treatment, including diet guidance, drug treatment and hemodialysis; those in the test group were asked to perform combined aerobic-resistance training three times a week and 45 minutes each time for 24 weeks during the dialysis period in addition to the routine treatment. Blood urea nitrogen, calculated the urea clearance index (Kt/V) and urea reduction rate (URR) before and after the intervention were collected to estimate their dialysis adequacy. Changes of the short form 36 questionnaire (SF-36) before and after the intervention were used to compare the quality of life between the two groups.  Results  After the execirse intervention for 24 weeks, Kt/V, URR, general health status (GH), physical function (PF), vitality (VT), mental health (MH) and total score of SF-36 were significantly higher in the test group than in the control group (t=2.435, 2.218, 2.675, 2.798, 3.188, 2.197 and 4.251 respectively; P=0.020, 0.033, 0.011, 0.008, 0.003, 0.034 and <0.001 respectively). In the test group after the exercise training for 24 weeks, Kt/V, URR, GH, PF, VT and total SF-36 score became significantly higher than their baseline levels (t=-2.880,          -7.543, -6.168, -3.587, -7.009 and -7.521 respectively; P=0.010, <0.001, <0.001, 0.002, <0.001 and <0.001 respectively).  Conclusion  Combined aerobic-resistance training can improve the dialysis adequacy and quality of life in MHD patients.

Key words: Maintenance hemodialysis, Combined aerobic-resistance training, Dialysis adequacy, Quality of life

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