中国血液净化

中国血液净化 ›› 2023, Vol. 22 ›› Issue (11): 853-855.doi: 10.3969/j.issn.1671-4091.2023.11.012

• 综述 • 上一篇    下一篇

促进自体动静脉内瘘成熟的潜在药物治疗方法

王 雪   于为民   

  1. 030032 太原，1山西医科大学第三医院(山西白求恩医院 山西医学科学院 同济山西医院)肾内科
  • 收稿日期:2023-07-10 修回日期:2023-08-23 出版日期:2023-11-22 发布日期:2023-11-12
  • 通讯作者: 于为民 E-mail:ywm4158963@163.com

Potential therapeutic approaches to promote the maturation of autologous arteriovenous fistula

WANG Xue, YU Wei-min   

  1. Department of Nephrology, The Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences Tongji Shanxi Hospital, Taiyuan 030032, China
  • Received:2023-07-10 Revised:2023-08-23 Online:2023-11-22 Published:2023-11-12
  • Contact: 030032 太原，1山西医科大学第三医院(山西白求恩医院 山西医学科学院 同济山西医院)肾内科 E-mail:ywm4158963@163.com

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摘要： 自体动静脉内瘘(autogenous arteriovenous fistula，AVF)是血液透析的首选血管通路，但内瘘建立后原发失败率高，主要表现为静脉新内膜增生(neointimal hyperplasia，NIH)，因此抑制NIH、改善内瘘通畅性是促进AVF成熟的主要挑战。本文综述了AVF的病理生理学，总结了抑制AVF静脉新内膜增生、促进内瘘成熟的潜在治疗方法。

关键词: 自体动静脉内瘘成熟, 静脉新内膜增生, 潜在治疗方法

Abstract: Autogenous arteriovenous fistula (AVF) is the vascular access of choice for hemodialysis. However, primary failure after fistula surgery occurs frequently, mainly in the form of venous neointimal hyperplasia (NIH). As a result, the main challenge to promote AVF maturation is the inhibition of venous NIH to maintain patency of the fistula. This article reviews the pathophysiology of AVF and summarizes the potential therapeutic approaches to inhibit venous NIH in AVF and to promote maturation of the endovascular fistula.

Key words: Maturation of autogenous arteriovenous fistula, Venous neointimal hyperplasia, Potential treatment

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