中国血液净化

中国血液净化 ›› 2017, Vol. 16 ›› Issue (10): 657-660.doi: 10.3969/j.issn.1671-4091.2017.010.004

• 专题 • 上一篇    下一篇

谁是丙型肝炎的传染源

张海莹1,饶慧瑛1   

  1. 1. 北京大学人民医院，北京大学肝病研究所，丙型肝炎和肝病免疫治疗北京市重点实验室
  • 收稿日期:2017-08-15 修回日期:2017-09-01 出版日期:2017-10-12 发布日期:2017-10-12
  • 通讯作者: 饶慧瑛 raohuiying@pkuph.edu.cn E-mail:raohuiying@pkuph.edu.cn

Who is the origin of hepatitis C virus infection?

  • Received:2017-08-15 Revised:2017-09-01 Online:2017-10-12 Published:2017-10-12

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摘要： 丙型肝炎病毒(hepatitis C virus,HCV)感染及所致疾病已成为全球的一个严重的社会公共卫生问题。HCV 感染的流行率在不断增加，HCV 感染没有有效的疫苗。抗-HCV 是HCV 初筛指标，但不是保护性抗体。HCV RNA 是HCV 感染的确诊指标，使用敏感性高的试剂可以提高检测的准确性对患者的诊断及治疗至关重要。当HCV 治愈或病毒自发清除后，高敏试剂检测不到HCV RNA，不存在传染性，但是抗-HCV 可以终生阳性。直接作用抗病毒药物(direct-acting antiviral agents，DAA)对HCV 治疗安全有效，包括肾功能损害患者。HCV 基因分型检测对指导个体化抗病毒方案治疗有重要临床价值。

Abstract: Hepatitis C virus (HCV) infection represents an important public health problem worldwide. The prevalence of HCV-related disease is increasing, and no vaccine is yet available. The presence of anti-HCV antibody is an indicator of HCV blood screening, but not a protective parameter. HCV RNA is a diagnostic marker for HCV infection. The highly sensitive assay increases the accuracy of detection and is critical for the diagnosis and treatment of HCV infection. When HCV RNA is not detected by high sensitivity assay, the patients are recovered from the disease and are not contagious anymore. However, anti-HCV antibody can be positive lifelong. Direct-acting antiviral agents (DAA) are safe and effective for the treatment of HCV infection. HCV genotyping is highly valuable in guiding individualized antiviral therapy.

Key words: Hepatitis C virus (HCV), Detection