中国血液净化

中国血液净化 ›› 2017, Vol. 16 ›› Issue (07): 459-462.doi: 10.3969/j.issn.1671-4091.2017.07.007

• 临床研究 • 上一篇    下一篇

血小板/淋巴细胞比值与维持性血液透析患者炎症状态的关系

张国娟1,黄雯1   

  1. 1. 首都医科大学附属北京同仁医院 肾内科
  • 收稿日期:2017-02-15 修回日期:2017-05-19 出版日期:2017-07-12 发布日期:2017-07-14
  • 通讯作者: 黄雯 huangw6@126.com E-mail:huangw6@126.com

The relationship between platelet/lymphocyte ratio and inflammation status in patients on maintenance hemodialysis

  • Received:2017-02-15 Revised:2017-05-19 Online:2017-07-12 Published:2017-07-14

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摘要： 目的探讨维持性血液透析(maintenance hemodialysis,MHD)患者血小板/淋巴细胞比值(platelet to lymphocyte ratio,PLR)与炎症的关系，为临床监测MHD 患者体内的炎症状态提供一个新的指标。方法以72 名稳定的MHD 患者为观察对象，以22 名健康体检者为对照，检测血常规及血生化，应用SPSS17.0 软件进行统计学分析,分析2 组患者PLR 等血液学指标之间的差异，根据PLR 平均数将MHD 患者分为2 组，分析2 组患者高敏C 反应蛋白(high sensitivity C reactive protein, hsCRP)、中性粒细胞/淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)、血浆白蛋白(albumin,ALB)等指标之间的差异，采用spearman 相关来分析PLR 与NLR、hsCRP 等的相关关系。结果MHD 患者血小板数及淋巴细胞数均显著低于正常对照组(t=5.903,P ﹤0.001；t=12.914,P ﹤0.001)；而MHD 患者PLR 为116.01 +41.49，显著高于正常对照组的75.31+19.44(t =-4.441,P﹤0.001)；MHD 患者NLR、hsCRP 显著高于正常对照组(t =-6.731,P﹤0.001；t=-2.752, P= 0.008)。MHD 患者PLR 平均数为116，PLR≥116 组患者血小板数、PLR、NLR、hsCRP 显著高于PLR＜116 组(t =- 3.676,P=0.001；t=- 9.81,P﹤0.001；t=- 4.114,P﹤0.001；t= -2.352,P=0.022)，淋巴细胞数显著低于PLR＜116 组(t=4.190,P﹤0.001)。MHD 患者PLR 与淋巴细胞数呈负相关(r=-0.574，P﹤0.001)，与血小板数(r=0.516，P﹤0.001)、NLR(r=0.625，P﹤0.001)、hsCRP(r=0.251，P=0.036)呈正相关。结论PLR 可以作为一个反映MHD患者系统炎症的新指标。

关键词: 维持性血液透析, 血小板/淋巴细胞比值, 炎症

Abstract: Objective To investigate the relationship between platelet/lymphocyte ratio (PLR) and inflammation status in patients on maintenance hemodialysis (MHD) in order to explore a new biomarker for the inflammation status in MHD patients. Methods A total of 72 stable MHD patients treated in Beijing Tongren Hospital and 22 healthy individuals as controls were enrolled in this study. SPSS17.0 software was used for statistical analyses. PLR and other laboratory parameters were compared between MHD patients and controls. MHD patients were further divided into two groups according to the mean value of PLR. Serum high sensitivity C reactive protein (hsCRP), neutrophil/lymphocyte ratio (NLR), albumin and other parameters were compared between the two MHD patient groups. The relationship between PLR, NLR and hsCRP was assessed using Spearman correlation. Results Platelet and lymphocyte counts were significantly lower in MHD patients than in normal controls (t=5.903, P<0.001 for platelet; t=12.914, P<0.001 for lymphocyte). PLR was 116.01+41.49 in MHD patient, significantly higher than 75.31+19.44 in normal controls (t=-4.441, P<0.001). NLR and hsCRP were also higher in MHD patients than in normal controls (t=-6.731, P<0.001 for NLR; t=-2.752, P=0.008 for hsCRP). The mean value of PLR was 116 in MHD patients. Platelet count, PLR, NLR, and hsCRP were significantly higher in the MHD patients with PLR ≥116 than in the MHD patients with PLR＜116 (t=-3.676, P=0.001 for platelet; t=-9.81, P<0.001 for PLR; t=-4.114, P<0.001 for NLR; t=-2.352, P=0.022 for hsCRP); lymphocyte count was significantly lower in those with PLR ≥116 than in those with PLR＜116 (t=4.190, P<0.001). PLR was negatively correlated with lymphocyte count (r=- 0.574, P<0.001) and positively correlated with platelet count (r=0.516, P<0.001), NLR (r=0.625, P<0.001) and hsCRP (r=0.251, P=0.036) in MHD patients. Conclusion PLR may be used as a new biomarker of systemic inflam-mation status in MHD patients.

Key words: maintenance hemodialysis, platelet to lymphocyte ratio, inflammation