关键词: 狼疮性肾炎, 肾微血管病变。

Abstract: 【Abstract】Renal vascular lesions are common in lupus nephritis. There are five major pathological types in renal biopsy samples: vascular immune complex deposits, arteriosclerosis, thrombotic microangiopathy, non-inflammatory necrotizing vasculopathy, and true renal vasculitis. They are correlated with disease activity, renal outcome and therapeutic strategy. The key mechanisms include endothelial cell activation and dysfunction, and immune system disorders. Moreover, mechanism- based individualized therapies for lupus nephritis are required.

Key words: Lupus nephritis, renal vasculopathy.