中国血液净化

中国血液净化 ›› 2020, Vol. 19 ›› Issue (03): 187-190.doi: 10.3969/j.issn.1671-4091.2020.03.011

• 血管通路 • 上一篇    下一篇

高通量透析对维持性血液透析患者自体动静脉内瘘7年次级通畅率的影响

孙春艳1,2,宋利2,莫雅文1,2,周丽芳1,2,郑淑倩3,陈迎归1,2,符霞1,2   

  1. 1 南方医科大学护理学院
    2广东省人民医院(广东省医学科学院)肾内科血液净化中心
    3 广州市第一人民医院南沙医院肾内科


  • 收稿日期:2019-12-12 修回日期:2019-12-30 出版日期:2020-03-12 发布日期:2020-03-12
  • 通讯作者: 符霞 fx-rena@163.com E-mail:13829706026@139.com
  • 基金资助:
    中央高校基本科研业务费专项资金资助(2018MS24)；广东省科技计划项目(2015A020210071)

Impact of high-flux dialysis on 7-year secondary patency rate of autologous arteriovenous fistula in hemodialysis patients

  1. 1 School of Nursing, Southern Medical University, Guangzhou 510515, China;
    2 Hemodialysis Center, Department of Nephrology, Guangdong Provincial People’s Hospital / Guangdong Academy of Medical Sciences, Guangzhou 510080, China;  3 Division of Nephrology, Guangzhou Nansha Central Hospital, Guangzhou 511457, China
  • Received:2019-12-12 Revised:2019-12-30 Online:2020-03-12 Published:2020-03-12

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摘要：

【摘要】目的 探讨高通量透析方式对维持性血液透析患者自体动静脉内瘘使用寿命的影响。方法 分析2012～2019 年于广东省人民医院血液净化中心规律透析治疗的患者491 例。采用倾向评分匹配法1：1 匹配高通组和低通组各54 例患者，比较2 组患者自体动静脉内瘘的7 年次级通畅率。结果 Kaplan-Meier生存分析提示高通组和低通组患者自体动静脉内瘘的7年次级通畅率无统计学差异[匹配前: 87.9%和84.3%，HR(95% CI) = 0.834 (0.449～1.548)，P = 0.566；匹配后：91.2%和82.1%，HR(95% CI) = 0.836 (0.224～3.120)，P = 0.790]。结论 高通量透析模式对维持性血液透析患者自体动静脉内瘘的使用寿命无显著影响。

关键词: 高通量透析, 自体动静脉内瘘, 维持性血液透析, 次级通畅率

Abstract:

【Abstract】Objective This study was conducted to investigate the impact of high-flux dialysis on lifespan of the autologous arteriovenous fistula in patients undergoing maintenance hemodialysis (MHD). Methods A total of 491 patients with regular hemodialysis at the Blood Purification Center of Guangdong Provincial People's Hospital from 2012 to 2019 were enrolled in this study. The propensity score matching method matched high-flux dialysis group (n=54) and low-flux dialysis group (n=54). The 7-year secondary patency rate of arteriovenous fistula was compared between the two groups. Results Kaplan-Meier survival analysis
showed no statistical difference in the 7-year secondary patency rate of autologous arteriovenous fistula between high- flux dialysis group and low- flux dialysis group [before matching: 87.9% vs. 84.3%, HR (95% CI) =0.834 (0.449~1.548), P=0.566; after matching: 91.2% vs. 82.1%, HR (95% CI) =0.836 (0.224~3.120), P=0.790]. Conclusion The high- flux dialysis mode had no significant impact on the lifespan of arteriovenous fistula in MHD patients.

Key words: High- flux dialysis, Arteriovenous fistula, Maintenance hemodialysis, Secondary patency rate

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