中国血液净化

中国血液净化 ›› 2020, Vol. 19 ›› Issue (11): 747-750.doi: 10.3969/j.issn.1671-4091.2020.11.007

• 临床研究 • 上一篇    下一篇

126 例维持性血液透析患者血镁水平及其影响因素

王熙坚1,祁月1,张叶1,张光第1,刘静1,陈晓岚1,戴厚永1   

  1. 1南通大学附属医院肾内科
  • 收稿日期:2020-04-14 修回日期:2020-08-19 出版日期:2020-11-12 发布日期:2020-11-05
  • 通讯作者: 戴厚永 daihy520@126.com E-mail:daihy520@126.com

Serum magnesium and its influencing factors in 126 patients with maintenance hemodialysis

  1. 1Department of Nephrology, the Affiliated Hospital of Nantong University, Nantong 226001, China
  • Received:2020-04-14 Revised:2020-08-19 Online:2020-11-12 Published:2020-11-05

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摘要： 【摘要】目的分析维持性血液透析(maintenance hemodialysis，MHD)患者血镁现状，探讨血镁影响因素及其与心脑血管事件的关系。方法筛选2018 年3 月在南通大学附属医院血液透析中心常规接受MHD 治疗的126 名患者，收集患者基本资料、临床指标，随访24 个月，每6 个月评估并且记录患者一般性情况及临床指标。结果126 名患者中血镁正常组[(1.01±0.08)mmol/L]50 例,高镁血症组[(1.27±0.16)mmol/L]76 例，无低镁血症患者。多因素Logistic 回归分析显示，血清白蛋白较高(OR=2.020, 95% CI 1.497～2.727, P＜0.001)、超敏C 反应蛋白较低(OR=0.904，95% CI 0.824～0.992，P=0.034)的MHD 患者血镁水平更高。多因素COX 比例风险模型显示血镁水平低是心脑血管事件的独立危险因素(HR=7.461，95% CI 2.005～27.766，P=0.003)。结论MHD 患者中血镁较高者其营养状态好，炎症水平低，且心脑血管事件患病风险低于正常血镁患者。MHD 治疗患者维持轻度高镁水平可能获益更多。

关键词: 维持性血液透析, 血镁, 心脑血管事件

Abstract: 【Abstract】Objective The study was to analyze the current situation of serum magnesium (Mg) in maintenance hemodialysis (MHD) patients, the influencing factors for serum Mg level, and the relationship between serum Mg and cardio-cerebrovascular events. Methods We analyzed 126 patients treated with MHD in March 2018 at the Blood Purification Center, the Affiliated Hospital of Nantong University. And they were followed up for 24 months. Results Multivariate logistic regression analysis showed that patients with higher serum albumin (OR=2.020, 95% CI: 1.497～2.727, P＜0.001) and lower high-sensitivity C-reactive protein
(OR=0.904, 95% CI: 0.824～0.992, P=0.034) had higher serum Mg level. Multivariate COX proportional hazard analysis showed that lower serum Mg was the independent risk factor for adverse cardio-cerebrovascular events (HR=7.461, 95% CI: 2.005～27.766, P=0.003). Conclusions MHD patients with hypermagnesemia had better nutritional status, lower inflammatory level, and lower risk of cardio-cerebrovascular events than patients with normal serum Mg. Therefore, maintenance of serum Mg at a slightly higher level may be beneficial for MHD patients.

Key words: Maintenance hemodialysis, Serum magnesium, Cardio-cerebrovascular event

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