中国血液净化

中国血液净化 ›› 2021, Vol. 20 ›› Issue (05): 320-323.doi: 10.3969/j.issn.1671-4091.2021.05.008

• 临床研究 • 上一篇    下一篇

维生素D 在血液透析患者体力活动和生活质量之间的中介作用研究

刘艳平1,陆悦2,李月红1,武向兰1,王冲1,杨画1,刘晔1   

  1. 1清华大学附属北京清华长庚医院肾内科，清华大学临床医学院，2北京大学护理学院
  • 收稿日期:2020-09-03 修回日期:2021-02-23 出版日期:2021-05-12 发布日期:2021-05-06
  • 通讯作者: 陆悦 luyue302@126.com 武向兰 wxla01657@btch.edu.cn E-mail:luyue302@126.com

Vitamin D as a mediator between physical activity and quality of life in hemodialysis patients

  1. 1Nephrology Department, Beijing Tsinghua Changgung Hospital, Tsinghua University School of Clinical Medicine, Beijing 102218, China;
    2Peking University School of Nursing, Beijing 100191, China
  • Received:2020-09-03 Revised:2021-02-23 Online:2021-05-12 Published:2021-05-06

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摘要： 【摘要】目的探讨维生素D 在维持性血液透析患者体力活动和生活质量之间的中介作用。方法采用国际体力活动问卷长版与简明健康状况量表，对92 例维持性血液透析患者进行体力活动与生活质量的调查，同时检测患者25(OH)D3水平。结果体力活动(对数)对生理健康总评的直接效应显著[c’=7.785(5.804,9.766), P＜0.001]，同时也存在以血清25(OH)D3 为中介的间接效应[ab=0.452(0.017, 1.203)]。结论血清25(OH)D3在血液透析患者的体力活动和生活质量(生理健康总评)间起部分中介作用，提高患者血清25(OH)D3水平可能有助于改善患者生活质量。

关键词: 维持性血液透析, 体力活动, 维生素D, 生活质量

Abstract: 【Abstract】Objective To explore the mediator effect of vitamin D between physical activity and quality of life in patients undergoing hemodialysis. Methods Physical activity and quality of life in the 94 maintenance hemodialysis patients were measured by the International Physical Activity Questionnaire of Long Version and Brief Health Status Scale. Serum 25(OH)D3 was also measured. Results Both the direct effect of physical activity (logarithm) on physical component summary [C’=7.785 (5.804, 9.766), P<0.001] and the indirect effect through serum 25(OH)D3 [ab=0.452(0.017,1.203)] were significant. Conclusion Vitamin D played as a mediator between physical activity and quality of life. Higher serum 25(OH)D3 level may help improve quality of life in hemodialysis patients.

Key words: Maintenance hemodialysis, Physical activity, Vitamin D, Quality of life

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