中国血液净化

中国血液净化 ›› 2022, Vol. 21 ›› Issue (11): 835-839.doi: 10.3969/j.issn.1671-4091.2022.11.011

• 综述 • 上一篇    下一篇

铁死亡在急性肾损伤中的研究进展

石 晶    郭兆安   

  1. 250014 济南，1山东中医药大学第一临床医学院 250014 济南，2山东中医药大学附属医院肾病科
  • 收稿日期:2022-05-05 修回日期:2022-07-25 出版日期:2022-11-11 发布日期:2022-11-12
  • 通讯作者: 郭兆安 E-mail:gza616@163.com

Research Progress of ferroptosis in Acute kidney Injury

SHI Jing, GUO Zhao-an   

  1. Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan 250014, China; 2Department of Nephrology, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014, China
  • Received:2022-05-05 Revised:2022-07-25 Online:2022-11-11 Published:2022-11-12
  • Contact: 250014 济南，山东中医药大学附属医院肾病科 E-mail:gza616@163.com

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摘要： 急性肾损伤(acute kidney injury,AKI)指各种病因引起短时间内肾功能急剧下降而出现的临床综合征，严重者可发展至肾衰竭甚则死亡。铁死亡的发生与谷胱甘肽过氧化物酶4、胱氨酸/谷氨酸反向转运体(cystine/glutamate antiporter,system xc-)、脂质代谢密切相关。铁死亡在缺血再灌注损伤(ischemia reperfusion injury,IRI)、横纹肌溶解(rhabdomyolysis，RM)和叶酸等多种病因所致AKI中均起到重要作用，因而抑制铁死亡在AKI的治疗中具有广阔的前景。本文系统综述了铁死亡参与AKI的作用机制及干预铁死亡的药物研究，探讨其作为治疗靶点的潜在前景。

关键词: 急性肾损伤, 铁死亡, 谷胱甘肽过氧化物酶4, 缺血再灌注损伤, 横纹肌溶解

Abstract: Acute kidney injury (AKI) is a clinical syndrome characterized by rapid deterioration of kidney function within a short period of time. In severe cases, AKI may lead to kidney failure or even death. Ferroptosis is closely related to glutathione peroxidase 4, cystine-glutamate antiporter (cystine/glutamate antiporter, system Xc-), and lipid metabolism. Ferroptosis plays an important role in ischemia reperfusion injury, rhabdomyolysis, and folic acid and other injuries derived AKI. Therefore, inhibition of ferroptosis may be useful for the treatment of AKI. This article systematically summarizes the mechanism of ferroptosis involved in AKI, the drugs to intervene ferroptosis, and ferroptosis as a potential therapeutic target of AKI.

Key words: Acute kidney injury, Ferroptosis, Glutathione peroxidase 4, Ischemia-reperfusion injury, Rhabdomyolysis

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