中国血液净化

中国血液净化 ›› 2023, Vol. 22 ›› Issue (1): 44-47.doi: 10.3969/j.issn.1671-4091.2023.01.010

• 综述 • 上一篇    下一篇

参与CKD-MBD的新因子

郭 歆   方敬爱  王蕊花   张晓东   刘文媛  常沁涛   

  1. 030001 太原，1山西医科大学第一临床医学院 030001 太原，2山西医科大学第一附属医院肾内科
  • 收稿日期:2022-06-06 修回日期:2022-08-12 出版日期:2023-01-12 发布日期:2023-01-12
  • 通讯作者: 王蕊花 E-mail:wrh6807@163.com

Novel factors involved in chronic kidney disease-mineral and bone disorder (CKD-MBD) 

GUO Xin, FANG Jing-ai, WANG Rui-hua, ZHANG Xiao-dong,  LIU Wen-yuan, CHANG Qin-tao   

  1. First Clinical College, Shanxi Medical University, Taiyuan 030001,China; 2Department of Nephrology, the First Hospital of Shanxi Medical University, Taiyuan 030001, China
  • Received:2022-06-06 Revised:2022-08-12 Online:2023-01-12 Published:2023-01-12
  • Contact: 030001 太原，2山西医科大学第一附属医院肾内科 E-mail:wrh6807@163.com

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摘要： 多种生物因子参与着慢性肾脏病矿物质和骨代谢异常(chronic kidney disease –mineral and bone disorder，CKD-MBD)的发生发展。除了经典的甲状旁腺激素(PTH)/维生素D轴理论，最近有研究发现成纤维细胞生长因子23(fibroblast growth factor23，FGF23)/Klotho、牙基质蛋白1(dentin matrix protein 1,DMP1)、分泌型蛋白Dickkopf-1(secretory protein Dickkopf 1，DKK1)和硬化蛋白(sclerostin)等因子也直接或间接参与着CKD-MBD的进展。本文将对上述因子的最新研究做一综述。

关键词: 慢性肾脏病矿物质和骨代谢异常, 成纤维细胞生长因子23/Klotho, 分泌型蛋白Dickkopf-1, 硬化蛋白, 牙基质蛋白1

Abstract: Many biological factors are involved in the occurrence and development of chronic kidney disease-mineral and bone disorder (CKD-MBD). In addition to the classic parathyroid hormone (PTH)/vitamin D axis theory, recent studies have found that fibroblast growth factor 23, FGF23/Klotho, dentin matrix protein 1 (DMP1), secretory protein DicKKOPF-1 (DKK1) and sclerostin are also directly or indirectly involved in the progression of CKD-MBD. This paper reviews the latest research on these factors.

Key words: Chronic kidney disease-mineral and bone disorder; , Fibroblast growth factor 23/Klotho, DKK1, Sclerostin, Dentin matrix protein1

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