中国血液净化

中国血液净化 ›› 2024, Vol. 23 ›› Issue (04): 286-289.doi: 10.3969/j.issn.1671-4091.2024.04.010

• 综述 • 上一篇    下一篇

活性维生素D对慢性肾脏病患者代谢及肾脏细胞功能的影响

郭子仪    张紫媛    方敬爱   

  1. 030001 太原，1山西医科大学第一临床医学院
    030001 太原，2山西医科大学第一医院肾内科
  • 收稿日期:2023-11-28 修回日期:2024-01-23 出版日期:2024-04-12 发布日期:2024-04-12
  • 通讯作者: 张紫媛 E-mail:ziye_402@163.com

Effects of the active form vitamin D on metabolism and kidney cell function in patients with chronic kidney disease

GUO Zi-Yi, ZHANG Zi-yuan, FANG Jing-ai   

  1. The First Clinical Medical School of Shanxi Medical University, Taiyuan 030001, China; 2Department of Nephrology, the First Hospital of Shanxi Medical University, Taiyuan 030001, China 
  • Received:2023-11-28 Revised:2024-01-23 Online:2024-04-12 Published:2024-04-12
  • Contact: 030001 太原，2山西医科大学第一医院肾内科 E-mail:ziye_402@163.com

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摘要： 维生素D(vitamin D,VD)是一种脂溶性类固醇衍生物，其不足或缺乏影响慢性肾脏病(chronic kidney disease,CKD)患者的钙磷稳态、甲状旁腺激素水平及血糖血脂代谢，从而导致一系列并发症的发生，降低CKD患者的生活质量及生存率。本文将围绕维生素D对慢性肾脏病患者代谢及肾脏细胞功能的作用机制进行综述，为CKD及其并发症的防治提供思路。

关键词: 维生素D, 慢性肾脏病, 钙磷稳态, 甲状旁腺激素, 糖脂代谢

Abstract: Vitamin D is a lipid-soluble steroid derivative. Insufficiency or deficiency of vitamin D in patients with chronic kidney disease (CKD) affects calcium-phosphorus homeostasis, parathyroid hormone (PTH) level and glucose and lipid metabolism, leading to the presence of a series of complications, lower quality of life and reduced survival rate in CKD patients. This article reviews the mechanism of vitamin D on metabolism and kidney cell function in CKD patients to provide bases for the prevention and treatment of CKD and its complications.

Key words: Vitamin D, Chronic kidney disease, Calcium-phosphorus homeostasis, Parathyroid hormone, Glucose and lipid metabolism

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