中国血液净化

中国血液净化 ›› 2025, Vol. 24 ›› Issue (07): 594-597.doi: 10.3969/j.issn.1671-4091.2025.07.011

• 综述 • 上一篇    下一篇

核苷酸结合寡聚化结构域受体蛋白3在腹膜纤维化中的作用机制研究进展

覃福生   张 林   

  1. 410006 长沙，1湖南师范大学附属长沙医院(长沙市第四医院)肾内科
  • 收稿日期:2025-02-10 修回日期:2025-03-24 出版日期:2025-07-12 发布日期:2025-07-12
  • 通讯作者: 张林 E-mail:397639438@qq.com
  • 基金资助:
    湖南省卫生健康委科研计划项目(D202303058217)

Research progress in the effect of nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) in the pathogenesis of peritoneal fibrosis

QIN Fu-sheng, ZHANG Lin   

  1. Department of Nephrology, Changsha Hospital Affiliated to Hunan Normal University (Changsha Fourth Hospital), Changsha 410006, China
  • Received:2025-02-10 Revised:2025-03-24 Online:2025-07-12 Published:2025-07-12
  • Contact: 410006 长沙，湖南师范大学附属长沙医院(长沙市第四医院)肾内科 E-mail:397639438@qq.com

摘要： 腹膜透析(peritoneal dialysis,PD)现已成为终末期肾病(end stage renal disease,ESRD)患者的重要治疗选择之一。然而，腹膜炎导致的腹膜纤维化往往是患者停止腹膜透析的主要原因。在腹膜纤维化的发展过程中，核苷酸结合寡聚化结构域受体蛋白3(NOD-like receptor protein 3，NLRP3)作为先天免疫系统的关键感应器，能够识别外源性病原体入侵及内源性细胞损伤，其激活后会促使白细胞介素(interleukin，IL)-1β和IL-18的成熟与释放，从而引发强烈的炎症反应，并在多种非细菌性炎症中扮演着重要角色。深入探究NLRP3的激活调控机制，为控制腹膜透析患者的腹膜纤维化提供理论依据。

关键词: 腹膜纤维化, 核苷酸结合寡聚化结构域受体蛋白3炎症小体, 腹膜炎

Abstract: Peritoneal dialysis (PD) has become one of the critical treatment options for patients with end-stage renal disease (ESRD). However, peritoneal fibrosis caused by peritonitis remains a key factor leading to discontinuation of PD. During the progression of peritoneal fibrosis, nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3), a pivotal sensor in the innate immune system, recognizes exogenous pathogen invasion and endogenous cellular damage, and activation of NLRP3 promotes the maturation and release of interleukin-1β (IL-1β) and IL-18, triggering robust inflammatory responses and playing a central role in various non-bacterial inflammatory processes. In-depth investigation into the regulatory mechanisms of NLRP3 activation provides a theoretical foundation for controlling peritoneal fibrosis in PD patients.

Key words: Peritoneal fibrosis, NOD-like receptor protein 3 inflammasome, Peritonitis

中图分类号: