中国血液净化

中国血液净化 ›› 2025, Vol. 24 ›› Issue (07): 609-613.doi: 10.3969/j.issn.1671-4091.2025.07.014

• 护理研究 • 上一篇    下一篇

基于生物电阻抗原理分析维持性血液透析患者并发肌少症的危险因素

滕彦娟   杨丽娜   汪年松   郭永平   

  1. 200233 上海，上海交通大学附属第六人民医院1护理部 2肾内科
  • 收稿日期:2024-09-18 修回日期:2025-05-09 出版日期:2025-07-12 发布日期:2025-07-12
  • 通讯作者: 杨丽娜 E-mail:18930177133@163.com
  • 基金资助:

Analysis of the risk factors for sarcopenia in maintenance hemodialysis patients based on the bioelectrical impedance principle

TENG Yan-juan, YANG Li-na, WANG Nian-song, GUO Yong-ping   

  1. Department of Nursing and 2Department of Nephrology, The Sixth People's Hospital affiliated to Shanghai Jiaotong University, Shanghai 200233, China
  • Received:2024-09-18 Revised:2025-05-09 Online:2025-07-12 Published:2025-07-12
  • Contact: 200233 上海，上海交通大学附属第六人民医院1护理部 E-mail:18930177133@163.com

摘要： 目的 分析维持性血液透析患者并发肌少症的危险因素，并据此探讨预防对策，为减少维持性血液透析患者并发肌少症提供一定依据。 方法 将2020年12月─2023年9月上海交通大学附属第六人民医院收治的312例维持性血液透析患者纳入此次回顾性研究，根据患者是否并发肌少症分为并发组(82例)、非并发组(230例)，通过单因素及多因素Logistic回归分析法筛选维持性血液透析患者并发肌少症的危险因素。 结果 经单因素及多因素Logistic分析结果显示，年龄≥65岁(OR=1.998，95% CI：1.188～3.358，P=0.009)、体质量指数(body mass index，BMI)＜21 kg/m2(OR=1.870，95% CI：1.037～3.374，P=0.038)、肾小球滤过率＜1 ml/min(OR=2.036，95% CI：1.120～3.702，P=0.020)、体内总水分较高(OR=1.881，95% CI：1.013～3.495，P=0.046)、血清超敏C反应蛋白(hs-CRP)水平较高(OR=1.802，95% CI：1.055～3.077，P=0.031)、握力值较低(OR=1.749，95% CI：1.082～2.827，P=0.023)、骨骼肌质量指数(appendicular skeletal muscle mass index，ASMI)较低(OR=1.944，95% CI：1.271～2.975，P=0.002)均为维持性血液透析患者并发肌少症的危险因素。 结论 维持性血液透析患者并发肌少症的危险因素较多，临床可据此筛选高危患者并采取相应预防对策，以降低肌少症发生率。

关键词: 血液透析, 肌少症, 危险因素

Abstract: Objective To analyze the risk factors for sarcopenia in patients with maintenance hemodialysis (MHD), so as to explore the preventive measures and the basis for reducing the incidence of sarcopenia in MHD patients.  Methods A total of 312 MHD patients admitted to the Sixth People's Hospital Affiliated to Shanghai Jiaotong University from December 2020 to September 2023 were included in this study. According to the presence and absence of sarcopenia, they were divided into the concurrent group (82 cases) and the non-concurrent group (230 cases). Univariate and multivariate logistic regression analyses were used to screen the risk factors for sarcopenia in MHD patients.  Results Univariate and multivariate logistic analyses showed that age ≥65 years (OR=1.998, 95% CI: 1.188～3.358, P=0.009), body mass index (BMI) ＜21 kg/m2 (OR=1.870, 95% CI: 1.037～3.374, P=0.038), glomerular filtration rate ＜1 mL/min (OR=2.036, 95% CI: 1.120～3.702, P=0.020), higher total body moisture (OR=1.881, 95% CI: 1.013～3.495, P=0.046), higher serum high sensitivity C-reactive protein (hs-CRP) level (OR=1.802, 95% CI: 1.013～3.495, P=0.031), low grip strength (OR=1.749, 95% CI: 1.082～2.827, P=0.023) and low skeletal muscle mass index (ASMI) (OR=1.944, 95% CI: 1.271～2.977, P=0.002) were the risk factors for sarcopenia in MHD patients.  Conclusion  There are many risk factors for sarcopenia in MHD patients. Clinically, the incidence of sarcopenia in MHD patients can be reduced by prevention and detection of the risk factors.

Key words: Hemodialysis, Sarcopenia, Risk factors

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