中国血液净化

中国血液净化 ›› 2025, Vol. 24 ›› Issue (11): 942-945.doi: 10.3969/j.issn.1671-4091.2025.11.014

• 综述 • 上一篇    下一篇

血液透析滤过：心血管保护性血液透析

杜 卉    左 力   

  1. 100028 北京，1费森尤斯医疗全球医疗办公室
    100044 北京，2北京大学人民医院肾内科
  • 收稿日期:2025-04-03 修回日期:2025-05-08 出版日期:2025-11-12 发布日期:2025-11-12
  • 通讯作者: 左力 E-mail:zuoli@bjmu.edu.cn

Hemodiafiltration: Cardioprotective hemodialysis

DU Hui1,  ZUO Li   

  1. Global Medical Office, Fresenius Medical Care, Beijing 100028, China; 2Department of Nephrology, Peking University People’s Hospital, Beijing 100044, China
  • Received:2025-04-03 Revised:2025-05-08 Online:2025-11-12 Published:2025-11-12
  • Contact: 100044 北京，2北京大学人民医院肾内科 E-mail:zuoli@bjmu.edu.cn

摘要： 血液透析滤过(hemodiafiltration,HDF)是一种结合了弥散和对流原理的透析技术。心血管疾病是透析患者的主要死亡原因，约占全因死亡的32.0%～55.9%。HDF能够显著降低心血管死亡风险，可能机制包括增强血流动力学稳定性、充分清除尿毒症毒素、纠正电解质紊乱、减轻炎症和氧化应激等。此外，HDF还可有效纠正贫血和改善营养不良状态，进一步降低心血管事件的发生风险。本文综述了HDF在心血管保护方面的研究证据及其可能机制。

关键词: 血液透析, 血液透析滤过, 心血管保护

Abstract: Hemodiafiltration (HDF) is a dialysis technique that combines the principles of diffusion and convection. Cardiovascular disease is the leading cause of death among dialysis patients, accounting for approximately 32% to 55.9% of all-cause mortality. Studies have shown that HDF can significantly reduce the risk of cardiovascular death. The potential mechanisms include enhancing hemodynamic stability, effectively removing uremic toxins, correcting electrolyte disturbances, and alleviating inflammation and oxidative stress. In addition, HDF may also effectively ameliorate anemia and improve malnutrition, thereby further reducing the risk of cardiovascular events. This article reviews the research evidence and potential mechanisms of HDF in cardiovascular protection.

Key words: Hemodialysis, Hemodiafiltration, Cardiovascular protection

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