中国血液净化

中国血液净化 ›› 2025, Vol. 24 ›› Issue (11): 946-950.doi: 10.3969/j.issn.1671-4091.2025.11.015

• 血液净化中心管理 • 上一篇    下一篇

高容量血液透析滤过：确保水和透析液质量以实现最佳患者管理

鲁伊·卢塞纳    贝尔纳·卡诺   

  1. 61352 巴特洪堡，¹德国费森尤斯医疗水处理-商品与服务贸易
    34090 蒙彼利埃，²法国蒙彼利埃大学医学系肾脏科
  • 收稿日期:2025-04-03 修回日期:2025-06-17 出版日期:2025-11-12 发布日期:2025-11-12
  • 通讯作者: 鲁伊·卢塞纳 E-mail:rui.lucena@inuvai.com

High volume hemodiafiltration: Ensuring water and dialysis fluid quality for optimal patient care

Rui Lucena, Bernard Canaud    

  1. VS Water Technology, Trading Goods & Services, Fresenius Medical Care, Bad Homburg 61352, Germany; 2Nephrology Department, Montpellier University, School of Medicine, Montpellier 34090, France
  • Received:2025-04-03 Revised:2025-06-17 Online:2025-11-12 Published:2025-11-12
  • Contact: 61352 巴特洪堡，¹德国费森尤斯医疗水处理-商品与服务贸易 E-mail:rui.lucena@inuvai.com

摘要： 透析液是通过多道精密工序制备的终产物，其质量直接关系到治疗效果与患者安全。要维持高标准的质量要求，必须实施严格的监测流程，并持续遵循各项质控措施。为确保在线对流治疗技术，如高容量血液透析滤过(hemodiafiltration，HDF)的安全实施，现已建立了严格的透析用水与超纯透析液的质量标准。这些标准不仅显著提升透析系统的生物相容性，更能降低患者全身炎症反应、改善红细胞生成素治疗效果，最终有望提高患者的长期生存率。本综述针对水处理系统及透析液质量管理标准提供了全面更新，特别聚焦相关标准在高容量HDF治疗优化中的关键作用。

关键词: 血液透析滤过, 透析液, 水质, 可持续性

Abstract: Dialysis fluid is the final product of a multi-step precision manufacturing process, with its quality directly impacting treatment efficacy and patient safety. Strict standards for dialysis water and ultrapure dialysis fluids have been established as essential prerequisites for online convective therapies, such as high-volume hemodiafiltration (HDF). These standards enhance the biocompatibility of the dialysis system, reduce systemic inflammation in dialysis patients, improve the response to erythropoiesis-stimulating agents, and ultimately have the potential to improve patient survival. This review provides a comprehensive update on the quality management requirements for water and dialysis fluids, with a specific focus on their role in optimizing high-volume hemodiafiltration.

Key words: Hemodiafiltration, Dialysis fluid, Water quality, Sustainability

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