中国血液净化

中国血液净化 ›› 2025, Vol. 24 ›› Issue (12): 975-978.doi: 10.3969/j.issn.1671-4091.2025.12.002

• 临床研究 • 上一篇    下一篇

异甘草酸镁联合杂合式血液净化治疗重症急性胰腺炎的效果观察

李国辉   卢甜美   张 利   殷瑶瑶   郭琼琼   王俊霞   

  1. 471000 洛阳，河南科技大学第一附属医院肾脏内科
  • 收稿日期:2025-03-13 修回日期:2025-09-30 出版日期:2025-12-12 发布日期:2025-12-12
  • 通讯作者: 王俊霞 E-mail:wangjunxia64812918@163.com
  • 基金资助:
    河南省医学科技攻关计划项目(LHGJ20210592)

Effect of magnesium isoglycyrrhizinate combined with heterozygotic blood purification in the treatment of severe acute pancreatitis

LI Guo-hui, LU Tian-mei, ZHANG Li, YIN Yao-yao, GUO Qiong-qiong, WANG Jun-xia   

  1. Department of Nephrology, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471000，China
  • Received:2025-03-13 Revised:2025-09-30 Online:2025-12-12 Published:2025-12-12
  • Contact: 471000 洛阳，1河南科技大学第一附属医院肾脏内科 E-mail:wangjunxia64812918@163.com

摘要： 目的  探讨异甘草酸镁与杂合式血液净化对重症急性胰腺炎(severe acute pancreatitis，SAP)治疗的效果。 方法 选择河南科技大学第一附属医院收治的SAP患者102例，随机分为采用杂合式血液净化治疗的单一组(n=51)、在血液净化治疗基础上加用异甘草酸镁的联合组(n=51)。比较2组总有效率、症状缓解情况、实验室生化指标、血清炎症因子指标、预后情况、不良反应。 结果  联合组总有效率高于单一组(χ2=4.320，P=0.038)，联合组患者腹痛、恶心呕吐缓解、住院时间低于单一组(t=9.112、13.679、6.537，均P＜0.001)；联合组急性生理学和慢性健康状况评分系统Ⅱ(acute physiology and chronic health evaluation II，APACHE Ⅱ)评分、C反应蛋白(C-reactive protein，CRP)、淀粉酶(amylase，AMS)、白细胞介素-8(interleukin-8，IL-8)、高迁移率族蛋白(high mobility group protein 1，HMGB1)水平低于单一组(t=5.386、15.051、12.850、12.312、13.771，均P＜0.001)；2组水肿、皮疹等不良反应发生率无统计学差异(χ2=0.917，P=0.338)。 结论  SAP患者接受异甘草酸镁+杂合式血液净化联合干预，可有效减轻炎症损伤，缩短住院时间。

关键词: 重症急性胰腺炎, 异甘草酸镁, 杂合式血液净化, 炎症因子, 不良反应

Abstract: Objective To investigate the therapeutic effect of magnesium isoglycyrrhizinate combined with hybrid blood purification in patients with severe acute pancreatitis (SAP), and its impacts on inflammatory indicators and prognosis.  Methods  A total of 102 SAP patients admitted to the First Affiliated Hospital of Henan University of Science and Technology were selected and randomly divided into two groups: the monotherapy group (n=51) and the combination  group (n=51). The monotherapy group received hybrid blood purification alone, while the combination group received magnesium isoglycyrrhizinate in addition to hybrid blood purification. The following outcomes were compared between the two groups: total effective rate, time to symptom relief, laboratory biochemical indicators, serum inflammatory markers, prognosis, and adverse reactions.  Results  The combination group showed a significantly higher overall effective rate (94.12%) compared with the monotherapy group (80.39%) (χ2=4.320, P=0.038). Additionally, the combination group had significantly shorter times to pain relief, nausea and vomiting relief, and hospitalization (t=9.112, t=13.679, t=6.537, all P＜0.001). The following indicators were significantly lower in the combination group than in the monotherapy group:  Acute Physiology And Chronic Health Evaluation II (APACHE II) score, C-reactive protein (CRP), amylase (AMS), interleukin-8 (IL-8), and high mobility group protein 1 (HMGB1) levels (t=5.386, t=15.051, t=12.850, t=12.312, t=13.771, all P＜0.001). There was no significant difference in the incidence of adverse reactions such as edema and rash between the two groups (χ2=0.917, P=0.338).  Conclusion  The combination of magnesium isoglycyrrhizinate and hybrid blood purification in SAP patients can effectively reduce inflammatory injury, shorten hospitalization time.

Key words: Severe acute pancreatitis, Magnesium isoglycyrrhizinate, Hybrid blood purification, Inflammatory factors, Untoward reactions

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