中国血液净化

中国血液净化 ›› 2025, Vol. 24 ›› Issue (12): 1010-1014.doi: 10.3969/j.issn.1671-4091.2025.12.009

• 综述 • 上一篇    下一篇

高容量血液透析滤过的实施：新加坡经验

苏甘达·萨克塞纳   南达库马尔·穆皮尔   亚基拉·吴   米林德·尼卡
  

  1. 122001 古尔冈，1费森尤斯医疗全球医疗办公室
    179101 新加坡，2费森尤斯医疗全球医疗办公室
    228510 新加坡，3新加坡伊丽莎白诺维娜医疗中心
    116675 迪拜，4费森尤斯医疗全球医疗办公室

  • 收稿日期:2025-06-30 修回日期:2025-10-07 出版日期:2025-12-12 发布日期:2025-12-12
  • 通讯作者: 米林德·尼卡姆 E-mail:Milind.Nikam@freseniusmedicalcare.com

Implementing high-volume hemodiafiltration: the Singapore experience

Sugandha Saxena, Nandakumar Mooppil, Akira Wu, Milind Nikam   

  1. Global Medical Office, Fresenius Medical Care, Gurgaon 122002, India; 2Global Medical Office, Fresenius Medical Care, 339914, Singapore; 3Mount Elizabeth Medical Centre, 228510, Singapore;4Global Medical Office, Fresenius Medical Care, Dubai 116675, United Arab Emirates
  • Received:2025-06-30 Revised:2025-10-07 Online:2025-12-12 Published:2025-12-12
  • Contact: 116675 迪拜，4费森尤斯医疗全球医疗办公室 E-mail:Milind.Nikam@freseniusmedicalcare.com

摘要： 高容量血液透析滤过(high volume hemodiafiltration,HVHDF)已被证实可以降低透析患者的死亡风险，但现有证据主要来自欧洲人群。近期新加坡费森尤斯医疗肾脏诊所(Fresenius Kidney Care，FKC)的临床数据显示：接受HDF治疗不同族裔群体的患者均能持续达到对流量目标，其中占患者主体的华裔人群疗效与国际基准相当。此外，与传统血液透析(hemodialysis，HD)相比，HVHDF可能降低住院负担，患者报告结局指标显示可更好地实现症状控制。新加坡经验证实HVHDF可安全、有效地融入多族裔群体的常规治疗，为提升亚洲透析疗效提供可推广的实践模式。本综述总结了新加坡实施HVHDF过程中的机构支持、运营管理和临床促进因素，旨在提炼其核心经验，为在亚洲更广泛地推广HDF提供借鉴。

关键词: 终末期肾病, 新加坡, 高容量血液透析滤过, 操作规程, 治疗监测

Abstract: High volume hemodiafiltration (HVHDF) has been proven to reduce the risk of death in dialysis patients, but the existing evidence mainly comes from the European population. Recent clinical data from Fresenius Kidney Care (FKC) Singapore demonstrated consistent achievement of convection volume targets across diverse ethnic groups. Patients with Chinese ethnicity, representing the majority, achieved outcomes comparable to global benchmarks. Moreover, HVHDF may offer reduced hospitalization burden compared to conventional HD, and better symptom control as adjudged by patient reported outcomes. Singapore’s experience affirms that HVHDF can be safely and effectively integrated into routine care, in a multi-ethnic group, offering a scalable model for improving dialysis outcomes in Asia. This review explores the institutional, operational, and clinical enablers that supported the implementation of HVHDF in Singapore to distil practical lessons applicable for broader HDF implementation across Asia.

Key words: End stage kidney disease, Singapore, High volume Hemodiafiltration, Operational protocols, Therapy monitoring

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