目的 探讨中性大孔吸附树脂灌流器HA380在脓毒症患者中进行血液灌流的应用价值，分析其对炎症水平、脏器功能及短期预后的影响。 方法 以吉林省一汽总医院2024年1月─2025年12月入院的80例脓毒症患者为研究样本，随机均分至对照组与观察组。对照组采用脓毒症标准化综合治疗，观察组在此基础上加用HA380血液灌流。对比2组治疗前后炎症指标、脏器功能指标、序贯器官衰竭评分、急性生理与慢性健康评分Ⅱ及28 d病死率，评价治疗效果。 结果  疗程结束后，观察组患者C反应蛋白、降钙素原、白细胞介素-6、肿瘤坏死因子-α、肌酐及总胆红素低于对照组(Z/t=2.933、-2.012、-2.926、-2.276、3.222、2.998，P=0.004、0.044、0.003、0.023、0.002、0.004)，氧合指数高于对照组(Z/t=-4.478，P＜0.001)，观察组序贯器官衰竭评分、急性生理与慢性健康评分Ⅱ低于对照组(Z/t=4.418、4.431，均P＜0.001)，生存曲线分析显示对照组病死率高于观察组(χ²=3.971，P=0.046)。 结论 HA380血液灌流可有效清除脓毒症患者体内炎症介质，改善脏器功能，降低器官衰竭风险与短期病死率，优化临床预后。

Objective To investigate the clinical value of hemoperfusion with the neutral macroporous adsorption resin cartridge HA380 in patients with sepsis, and to analyze its effects on inflammatory levels, organ function, and short‑term prognosis. Methods  Eighty patients with sepsis admitted to FAW General Hospital of Jilin Province from January 2024 to December 2025 were enrolled and randomly divided equally into a control group and an observation group. The control group received standard comprehensive treatment for sepsis, while the observation group received additional HA380 hemoperfusion. Inflammatory markers, organ function indicators, Sequential Organ Failure Assessment (SOFA) score, Acute Physiology and Chronic Health Evaluation II (APACHE II) score, and 28‑day mortality were compared between the two groups before and after treatment to evaluate the therapeutic efficacy. Results After the treatment course, the observation group showed significantly lower levels of C‑reactive protein, procalcitonin, interleukin‑6, tumor necrosis factor‑α, creatinine, and total bilirubin than the control group (Z/t=2.933, ‑2.012, ‑2.926, ‑2.276, 3.222, 2.998; P=0.004, 0.044, 0.003, 0.023, 0.002, 0.004, respectively), and a significantly higher oxygenation index (Z/t=‑4.478, P<0.001). The observation group also had lower SOFA and APACHE II scores than the control group (Z/t=4.418, 4.431, both P<0.001). Survival curve analysis showed that the mortality rate in the control group was higher than that in the observation group (χ²=3.971, P=0.046). Conclusion  HA380 hemoperfusion can effectively remove inflammatory mediators in septic patients, improve organ function, reduce the risk of organ failure and short‑term mortality, and optimize clinical prognosis.