中国血液净化

›› 2002, Vol. 1 ›› Issue (11): 26-28.

• 论著 • 上一篇    下一篇

交感神经活性对血液透析患者高血压的作用

师延斌 袁丽洁 李险峰   

  1. 475001 开封，河南大学第一附属医院肾内科（师延斌 袁丽洁）475003 开封，中国人民解放军 95900部队医院（李险峰）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2002-11-19 发布日期:2002-11-19

  • Received:1900-01-01 Revised:1900-01-01 Online:2002-11-19 Published:2002-11-19

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摘要： 【摘要】目的 研究以血浆肾上腺素和去甲肾上腺素为代表的交感神经系统在血液透析患者高血压发病中的作用。 方法 选取12例血液透析高血压患者，6例男性、6例女性,年龄30～60岁，作为高血压组。12例血压正常的血液透析患者，作为对照组。每例患者分别于透析前后采集血液标本检测血浆肾上腺素和去甲肾上腺素含量。同时记录每例患者透析前后平均动脉压(MAP)。结果 高血压组的平均动脉压透析前后无改变。高血压组的血浆去甲肾上腺素水平高于对照组，血液透析后无明显变化。血浆肾上腺素—去甲肾上腺素水平与MAP或透析间期体重增加无相关关系。结论 以儿茶酚胺含量变化表示的交感神经活性参于血液透析患者的高血压的发生。

关键词: 交感神经, 血液透析, 高血压

Abstract:

【Abstract】Objective To study the role of sympathetic nervous system expressed by plasma adrenaline and noradrenaline level in the hypertension of hemodialysis patients. Methods 12 hypertension hemodialysis patients were taken into the hypertension group, 6 male, 6 female, aged from 30 to 60 years old. Another 12 normotensive hemodialysis patients were as the control group. Each patient's blood sample was taken at pre and post hemodialysis procedure for plasma noradrenaline adrenaline level, meanwhile, mean arterial blood pressure (MAP) was measured. Results Post-dialysis MAP in comparison to pre-dialysis MAP was similar in hypertension hemodialysis patients. Plasma adrenaline and noradrenaline levels in hypertension group were higher than control group and were not different between pre and post dialysis. These levels were not correlated with MAP or body weight alterations. Conclusion It is suggested that sympathetic activity, as it was expressed by plasma catecholamine alterations, is associated with hemodialysis hypertension.

Key words: Hemodialysis, Hypertension