【摘要】 目的 观察重组人促红细胞生成素对尿毒症患者血清瘦 素水平的影响。方法 30例尿毒症患者早八时抽空腹血，用酶标法测定重组人促红细胞生成素应用前及用药二周、四周、八周后的血清瘦素水平。结果男(6.24±4.18)μg/L，女(9.86±5.86)μg/L；重组人促红细胞生成素应用前尿毒症患者血清瘦的水平为男(21.18±7.42)μg/L，女(29.04±6.48)μg/L；应用二周后为男(16.24±5.88)μg/L，女(20.28±6.36)μg/L；四周后为男(13.76±4.24)μg/L，女(16.82±5.25)μg/L；八周后为(14.84±6.496)μg/L，女(18.47±5.34)μg/L。结论 尿毒症患者血清瘦素水平明显高于正常人；红细胞生成素的应用能够有效降低患者的血清瘦素水平、增加食欲、改善营养状态。

【Abstract】Objective To observe the effects of rhuEPO on serum leptin levels in patients with ESRD. Methods serum leptin levels were determined by ELISA before and after 2、4、8 weeks of rhuEPO used in ESRD patients on 8am. Results In normal controls, serum leptin levels was (6.24±4.18) μg/L in men, (9.86±5.86) μg/L in wemen.Be fore rhuEPO used, it was (21.18±7.42) μg/L in men, (29.04±6.48) μg/L in wemen;after 2nd week rhu EPO used, it was (16.24±5.88) μg/L in men, (20.28±6.36) μg/L in wemen; after 4nd week rhu EPO used was (13.76±4.24) μg/L in men, (16.82±5.25) μg/L in wemen; and was (14.84±6.46) μg/L in men, (18.47±5.34) μg/L in wemen after 8nd week rhuEPO used. Conclusion Serum leptin levels in patients with ESRD are significantly increased; rhuEPO may significantly reduce the serum leptin levels in patients with ESRD.