【摘要】目的 体外观察树脂血液灌流器对重型肝炎患者血浆中毒性物质的清除作用。方法 收集重型肝炎患者的血浆，在体外循环通过树脂灌流器吸附1至2小时，评价其在流速80～120ml/min时对肝肾功能的影响及对血氨、内毒素和细胞因子的清除作用。结果 吸附后血浆中总胆红素、内毒素、白细胞介素1β和肿瘤坏死因子α水平显著下降，肌酐、尿素氮下降不多，血氨、电解质和白介素6无明显变化。结论 树脂体外吸附重型肝炎患者血浆中胆红素、内毒素、细胞因子有效，说明其对重型肝炎可能有较好的治疗作用。

【Abstract】Objective To evaluate the in vitro abilities of adsorbing resin to remove toxin from plasma of severe hepatitis patients. Methods The plasma of severe hepatitis patients was collected and recirculated through the resin column for one or two hours. Regular blood tests including liver and renal function were performed and the removal of blood ammonia, endotoxin and cytokines was evaluated at 80～120ml/min flow rates. Results The study showed significant decreases in levels of plasma total bilirubin, tumor necrosis factor-alpha, interleukin-1β and endotoxin. Blood creatinine and urea nitrogen decreased slightly. No changes were observed in blood anmonia, electrolure and interleukin-6. Conclusion Adsorbing resin can adsorb bilirubin and cytokines in the blood of severe hapatitis patients. The applying prospect is very optimistic.