中国血液净化

›› 2003, Vol. 2 ›› Issue (1): 23-25.

• 论著 • 上一篇    下一篇

树脂血液灌流器对重型肝炎治疗作用的体外观察

王泽文 王英杰 文红伟 王宇明   

  1. 400038 重庆，第三军医大学西南医院全军感染病研究所
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2003-01-19 发布日期:2003-01-19

  • Received:1900-01-01 Revised:1900-01-01 Online:2003-01-19 Published:2003-01-19

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摘要： 【摘要】目的 体外观察树脂血液灌流器对重型肝炎患者血浆中毒性物质的清除作用。方法 收集重型肝炎患者的血浆，在体外循环通过树脂灌流器吸附1至2小时，评价其在流速80～120ml/min时对肝肾功能的影响及对血氨、内毒素和细胞因子的清除作用。结果 吸附后血浆中总胆红素、内毒素、白细胞介素1β和肿瘤坏死因子α水平显著下降，肌酐、尿素氮下降不多，血氨、电解质和白介素6无明显变化。结论 树脂体外吸附重型肝炎患者血浆中胆红素、内毒素、细胞因子有效，说明其对重型肝炎可能有较好的治疗作用。

关键词: 树脂, 血液灌流, 重型肝炎, 内毒素, 细胞因子

Abstract: 【Abstract】Objective To evaluate the in vitro abilities of adsorbing resin to remove toxin from plasma of severe hepatitis patients. Methods The plasma of severe hepatitis patients was collected and recirculated through the resin column for one or two hours. Regular blood tests including liver and renal function were performed and the removal of blood ammonia, endotoxin and cytokines was evaluated at 80～120ml/min flow rates. Results The study showed significant decreases in levels of plasma total bilirubin, tumor necrosis factor-alpha, interleukin-1β and endotoxin. Blood creatinine and urea nitrogen decreased slightly. No changes were observed in blood anmonia, electrolure and interleukin-6. Conclusion Adsorbing resin can adsorb bilirubin and cytokines in the blood of severe hapatitis patients. The applying prospect is very optimistic.

Key words: Hemoperfusion, Severe hepatitis, Endotoxin, Cytokine