中国血液净化

›› 2003, Vol. 2 ›› Issue (1): 9-10.

• 论著 • 上一篇    下一篇

慢性肾衰竭血液透析患者EPO的疗效与ACEI关系的研究

汪关煜 钱莹 朱萍 吴佩 沈平雁 陈楠 张金元 陆石 田军 孙晶   

  1. 200025 上海，上海第二医科大学附属瑞金医院肾内科(汪关煜，钱莹，朱萍，吴佩，沈平雁，陈楠)上海，解放军455医院肾内科(张金元，陆石，田军，孙晶)
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2003-01-19 发布日期:2003-01-19

  • Received:1900-01-01 Revised:1900-01-01 Online:2003-01-19 Published:2003-01-19

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摘要： 【摘要】目的 为了解CRF血液透析患者EPO治疗贫血的疗效与ACEI之间的关系。方法 对透析稳定、充分，伴有贫血与高血压患者，排除了缺铁、感染、铝中毒、继发性甲旁亢后，在应用EPO的同时，观察使用与不使用ACEI两组间贫血纠正的疗效。用随机对照的方法进行前瞻性的分析。结果 用ACEI组，EPO纠正贫血的达标率（Hb≥100g/L,Hct≥30%）为20.8%，不用ACEI组为55.5%。在用ACEI组达标的5例仅用ACEI10mg/d,未达标者ACEI用量较大，其中4例>40mg/d。结论 较大剂量的ACEI对EPO纠正贫血有一定的影响。

关键词: 肾性贫血, 促红细胞生成素, 转换酶抑制剂

Abstract:

【Abstract】Objective To evaluate the effects of ACE inhibitor treatment on erythropoiesis in chronic hemodialysis patients. Methods 51 hemodialysis patients with anemia and hypertension, rule of iron deficiency, infection, aluminum intoxication and hyperparathyroidism were divided into 2 groups, based on whether or not they were administered ACEI, into the ACEI group(n=24) and the non-ACEI group(n=27), and prospective randomised comparisons were made of hematocrit(Hct) and hemoglobin (Hb). Results Among the patients in the non-ACEI group, the percentage of the patients achieving a hemoglobin response, defined as an increase>or=100g/L, hemotocrit >or =30% was 55.5%. While in the ACEI group, the percentage was 20.8%. the dose of ACEI in 5 patients achieving hemoglobin response were 10mg/d for each, but in 4 patients not achieving hemoglobin response were >40 mg/d for each. Conclusion Large dose of ACEI may decrease hemoglobin in chronic hemodialysis patients.

Key words: Erythropoietin, Angiotension-converting enzyme inhibitors 