中国血液净化

›› 2003, Vol. 2 ›› Issue (12): 648-650.

• 论著 • 上一篇    下一篇

ANP、cGMP 和ICVD对血液透析患者干体重评价的意义

刘惠兰 周亦伦 段晓峰   

  1. 100038 北京，首都医科大学附属复兴医院肾内科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2003-12-19 发布日期:2003-12-19

  • Received:1900-01-01 Revised:1900-01-01 Online:2003-12-19 Published:2003-12-19

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摘要： 目的 观察血浆心钠素 （ANP）、环磷酸鸟苷（cGMP）和彩色超声心动测定下腔静脉直径(ICVD) 对评价血液透析患者干体重的作用。方法 利用临床经验法和观察指标评价并调整40例血液透析患者的干体重，检测透析前后各观察指标的变化，并与32例正常对照组比较。结果 透析后ANP、cGMP较透析前明显降低，但仍明显高于对照组；临床判断有容量过负荷的患者，降低干体重后，ANP和cGMP明显降低；用ICVD评价为超负荷的患者，其ANP和cGMP明显高于低负荷及正常负荷者。结论 血浆ANP、cGMP的测定可较好反映高容量状态，IVCD对高容量及低容量状态均有良好反映。

关键词: 血液透析, 干体重, 心钠素, 环磷酸鸟苷, 下腔静脉直径

Abstract:

Objective To observe the effects of ANP, cGMP and the inferior caval vein diameter (ICVD) on evaluating the dry body weight of hemodialysis patients. Methods Assessed and regulated the dry body weight of 40 maintenance hemodialysis patients with clinical methods and ANP, cGMP and ICVD. Then, compared the changes of these indicators before and after hemodialysis and with 32 normal controls. Results The levels of plasma ANP and cGMP after hemodialysis were significantly lower than before, but all of them were still higher significantly than the contral. In the overload patients judged by clinical methods, the ANP and cGMP significantly decreased after reducing their dry body weight. The plasma ANP and cGMP levels in the overload patients evaluated by ICVD were higher than download and normal patients. Conclusions The plasma levels of ANP and cGMP were better indicators to assess the overload status in hemodialysis patients. Whereas the ICVD can be used to evaluate the overload and download status.

Key words: Dry body weight, ANP, cGMP, ICVD 