中国血液净化

›› 2003, Vol. 2 ›› Issue (5): 248-250.

• 论著 • 上一篇    下一篇

慢性肾功能衰竭维持性血液透析患者血清心肌肌钙蛋白的变化

赵卫红 戎其飞 王笑云 潭若芸 毛慧娟 沈 霞   

  1. 210029 南京，南京医科大学第一附属医院肾内科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2003-05-19 发布日期:2003-05-19

  • Received:1900-01-01 Revised:1900-01-01 Online:2003-05-19 Published:2003-05-19

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摘要： 目的 观察慢性肾功能衰竭（ CRF）维持性血液透析患者心肌肌钙蛋白(cTnI)的异常变化。 方法 应 用双抗夹心酶联免疫吸附法（ELISA）检测115例维持性血液透析患者和64例正常人的cTnI。 结果 慢性肾功能衰竭组的血清cTnI水平为(0.20±0.52)ng/ml，显著高于健康对照组(0.03±0.05)ng/ml（ P<0.05）。115例慢性肾功能衰竭维持性血液透析患者中31（27.0%）例有不同程度的胸闷、心悸等症状；有症状患者血清 cTnI为(0.49±0.93)ng/ml，显著高于无症状患者(0.09±0.11)ng/ml， P<0.05。无症状者中仍有10例（11.9%）血清 cTnI增高。结论 慢性肾功能衰竭血液透析患者cTnI明显高于正常人群，其中部分无临床症状，提示慢性肾功能衰竭患者心肌损伤较为普遍且部分为亚临床损伤。

关键词: 慢性肾功能衰竭, 肌钙蛋白I, 心肌损伤

Abstract: Objective To explore change of serum troponin I（cTnI） in hemodialysis patients with chronic renal failure. Methods By enzyme-linked immunosorbent assay(ELISA),the level of Serum cTnI were measured in 115 patients with chronic renal failure undergoing hemodialysis and 64 healthy persons. Results The level of serum cTnI in hemodialysis patients were higher than those of healthy persons significantly ， (P＜0.01). And the level of serum cTnI is different between the hemodialysis patients with and without symptom of breathless (P＜0.01). But serum cTnI in 10 cases（11.9%）without symptom were still higher than normal. Conclusions Myocardium impairments were prevalent in hemodialysis patients,and sometimes are subclinical.

Key words: Troponin I, Myocardium impairments 