中国血液净化

›› 2003, Vol. 2 ›› Issue (6): 311-314.

• 论著 • 上一篇    下一篇

低分子肝素对血液透析患者脂代谢影响的回顾性分析

郭彦聪 张 凌   

  1. 071000 保定，河北省保定市人民医院肾内科血液透析室(郭彦聪) 100029 北京，北京中日友好医院血液净化中心(张凌)
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2003-06-19 发布日期:2003-06-19

  • Received:1900-01-01 Revised:1900-01-01 Online:2003-06-19 Published:2003-06-19

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摘要： 目的 调查低分子肝素（low molecular weight heparin，LMWH）对血液透析患者脂代谢的影响。方法 采用回顾性分析的方法调查34例维持血液透析患者应用普通肝素（18例）(unfractionated heparin，UFH)和LMWH(16例)抗凝对血脂和脂蛋白的影响。结果 LMWH组的TG、Tch 、LDL、Apo-B在第12个月（P<0.05）及第6个月（无显著差异）均低于 UFH组； 而HDL与之相反；LMWH组的TG、Tch、LDL、Apo-B在第12个月低于第0个月（P<0.05）；而 UFH组TG（无显著差异）、Tch（P<0.05）、LDL、Apo-B高于第0 个月。结论 长期使用LMWH不加重血液透析患者脂代谢的紊乱，相反可部分矫正已有的脂代谢的紊乱。

关键词: 低分子肝素, 脂代谢, 肝素, 血液透析, 终末期肾功能衰竭

Abstract: Objective To Investigate the effect of low molecular weight heparin (LMWH)on lipid metabolism in end-stage renal failure hemeodialysis patients. Methods Triglycerides (TG) and cholesterol (CH) lipoproteins and apolipoprotein of 18 hemeodialysis patients who used unfractionated heparin(UFH)，and 16 patients who used(LMWH) was investigated by retrospective analysis. Results Compare with UFH, decrease of TG、Tch 、LDL、Apo-B and increase of HDL was observed in LMWH group on 6 months and 12 months; compare with 0 months, decrease of TG、Tch 、LDL、Apo-B and increase of HDL was observed on 6 months and 12 months in LMWH group and increase of Tch、LDL、Apo-B was observed on 12 months in of UFH group. Conclusion In hypertriglyceridaemic HD patients, LMWH improved metabolism of triglycerides and cholesterol lipoproteins and apolipoprotein.

Key words: Lipid metabolism, Unfractionated heparin（UFH）, Hemeodialysis, End-stage renal failure 