中国血液净化

›› 2003, Vol. 2 ›› Issue (8): 439-441.

• 人工肝 • 上一篇    下一篇

人工肝支持系统治疗慢性重型肝炎时对电解质影响的临床观察

庄 鹏 江元森 李学俊 谢俊强 邓 友 王海霞 姚集鲁   

  1. 510630 广州，中山大学第三医院人工肝研究室
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2003-08-19 发布日期:2003-08-19

  • Received:1900-01-01 Revised:1900-01-01 Online:2003-08-19 Published:2003-08-19

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摘要： 目的 观察慢性重型肝炎患者 CHDF(持续缓慢血液透析滤过)+PE（血浆置换）治疗时对血清电 解质的影响情况。方法 随机选取55例慢性重型肝炎患者，其中并发低钾血症21例，低钠血症20例，低氯血症27例，在内科综合治疗的基础上加用日产KM-8800血浆交换仪并联用JUN-500血液透析滤过仪进行人工肝治疗，观察治疗前后的血清K+、Na+、Cl-、HCO3-、Ca2+的变化情况。结果 人工肝治疗前后血清K+、Na+、Cl-水平有明显差异（P<0.05）, HCO3-、Ca2+水平无明显变化( P>0.05）。结论 CHDF+PE 治疗慢性重型肝炎可有效纠正电解质紊乱,保持内环境平衡。

关键词: 持续缓慢血液透析滤过, 血浆置换, 重型肝炎, 电解质

Abstract: Objective To observe the influence on serum electrolyte in the treatment of chronic severe hepatitis with continuous hemodiafiltration(CHDF) plus plasma exchange(PE). Methods Fifty-five patients with chronic severe hepatitis were selected randomly, 21cases of them complicated with hypokalemia, 20 cases complicated with hyponatremia, 27 cases complicated with hypochloraemia. All patients were treated with PE and CHDF with an artificial liver support system of KM-880 and JUN-500 on the basis of general treatment before and after the treatment, the serum levels of electrolyte including K+、Na+、Cl-、HCO3-、Ca+ + were compared. Results The patients' serum levels of electrolyte K+、Na+、Cl- showed significant difference after the treatment (P<0.05）, but the serum levels of electrolyte HCO3- 、Ca+ +、have a different result（P>0.05）. Conclusion CHDF plus PE can effectively rectify the disturbance of electrolyte and keep the balance of internal environment of the patients with chronic severe hepatitis.

Key words: Plasma exchange, Severe hepatitis, Electrolytes